The Impact of Methylprednisolone Pulses during Relapses of Multiple Sclerosis on the Kinetics of Anti-Interferon-Beta Antibodies.

Authors :: Giantzi V
Karapanayiotides T
Lagoudaki R
Poulatsidou KN
Lourbopoulos A
Daniilidis M
Taskos N
Milonas I
Grigoriadis N
Source :: European neurology [Eur Neurol] 2016; Vol. 75 (1-2), pp. 82-8. Date of Electronic Publication: 2016 Feb 12.
Publication Year :: 2016
Abstract: Background/aims: We assessed the, hitherto unknown, impact of intravenous methylprednisolone (ivMP) pulses during relapses of multiple sclerosis (MS) on the kinetics of anti-interferon-beta neutralizing antibodies (Nabs) and binding antibodies (Babs).<br />Methods: Babs (ELISA) and Nabs (antiviral cytopathic effect assay) titers were evaluated before, immediately after and at 1 month following ivMP in 60 MS patients.<br />Results: ivMP reduces Nabs and Babs titers for at least 1 month. Baseline titers determine Nabs and Babs seronegativity at the end of ivMP. Clinical response to ivMP tends to be better in Nabs(+) patients.<br />Conclusion: Sampling for Nabs/Babs should be avoided during or shortly after ivMP to avoid transient positive or negative results that may obscure the decision to switch treatment.<br /> (© 2016 S. Karger AG, Basel.)

Subjects :: Administration, Intravenous
Adult
Enzyme-Linked Immunosorbent Assay
Female
Humans
Interferon-beta therapeutic use
Kinetics
Methylprednisolone therapeutic use
Antibodies, Neutralizing blood
Interferon-beta immunology
Methylprednisolone administration & dosage
Multiple Sclerosis drug therapy
Neuroprotective Agents administration & dosage

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