XRF-measured bone lead (Pb) as a biomarker for Pb exposure and toxicity among children diagnosed with Pb poisoning.

Authors :: Specht AJ
Lin Y
Weisskopf M
Yan C
Hu H
Xu J
Nie LH
Source :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals [Biomarkers] 2016; Vol. 21 (4), pp. 347-52. Date of Electronic Publication: 2016 Feb 09.
Publication Year :: 2016
Abstract: Childhood lead (Pb) poisoning remains a global issue, especially in industrial areas. In this study, 115 children with average age 5.7 years were recruited as either patient diagnosed with Pb poisoning or controls at Xinhua Hospital in China. The subjects' bone Pb was measured with a K-shell X-ray fluorescence (KXRF) and a portable X-ray fluorescence (XRF) system. A significant correlation between KXRF bone Pb and blood Pb and portable XRF and KXRF measurements were observed. The half-life of blood-lead was calculated to be 9.96 ± 3.92 d. Our results indicate that bone is a useful biomarker for Pb in children.

Subjects :: Child
Child, Preschool
China
Humans
Lead pharmacokinetics
Biomarkers analysis
Bone and Bones chemistry
Environmental Exposure
Lead analysis
Lead Poisoning diagnosis
Spectrometry, X-Ray Emission methods

Language :: English
ISSN :: 1366-5804
Volume :: 21
Issue :: 4
Database :: MEDLINE
Journal :: Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals
Publication Type :: Academic Journal
Accession number :: 26856822
Full Text :: https://doi.org/10.3109/1354750X.2016.1139183

Full Text Access

Tools