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Thrombus aspiration in patients with large anterior myocardial infarction: A Thrombus Aspiration in ST-Elevation myocardial infarction in Scandinavia trial substudy.
- Source :
-
American heart journal [Am Heart J] 2016 Feb; Vol. 172, pp. 129-34. Date of Electronic Publication: 2015 Nov 22. - Publication Year :
- 2016
-
Abstract
- Background: The TASTE trial did not demonstrate clinical benefit of thrombus aspiration (TA). High-risk patients might benefit from TA.<br />Methods: The TASTE trial was a multicenter, randomized, controlled, open-label trial obtaining end points from national registries. Patients (n = 7,244) with ST-segment elevation myocardial infarction (STEMI) undergoing percutaneous coronary intervention (PCI) were randomly assigned 1:1 to TA and PCI or to PCI alone. We assessed the 1-year clinical effect of TA in a subgroup with potentially large anterior STEMI: mid or proximal left anterior descending coronary artery infarct lesion, thrombolysis in myocardial infarction 0 to 2 flow, and symptom onset to PCI time ≤5 hours. In this substudy, patient eligibility criteria corresponded to that of the INFUSE-AMI study.<br />Results: In total, 1,826 patients fulfilled inclusion criteria. All-cause mortality at 1 year of patients randomized to TA did not differ from those randomized to PCI only (hazard ratio [HR] 1.05, 95% CI 0.74-1.49, P = .77). Rates of rehospitalization for myocardial infarction, heart failure, and stent thrombosis did not differ between groups (HR 0.87, 95% CI 0.51-1.46, P = .59; HR 1.10 95% CI 0.77-1.58, P = .58; and HR 0.75, 95% CI 0.30-1.86, P = .53, respectively). This was also the case for the combined end point of all-cause mortality and rehospitalization for myocardial infarction, heart failure, or stent thrombosis (HR 1.00, 95% CI 0.79-1.26, P = .99).<br />Conclusion: In patients with STEMI and large area of myocardium at risk, TA did not affect outcome within 1 year.<br /> (Copyright © 2015 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Aged
Anterior Wall Myocardial Infarction diagnosis
Anterior Wall Myocardial Infarction etiology
Coronary Angiography
Coronary Thrombosis complications
Coronary Thrombosis mortality
Female
Follow-Up Studies
Humans
Male
Middle Aged
Percutaneous Coronary Intervention
Prospective Studies
Registries
Survival Rate trends
Sweden epidemiology
Treatment Outcome
Anterior Wall Myocardial Infarction surgery
Coronary Thrombosis therapy
Electrocardiography
Suction methods
Thrombectomy methods
Subjects
Details
- Language :
- English
- ISSN :
- 1097-6744
- Volume :
- 172
- Database :
- MEDLINE
- Journal :
- American heart journal
- Publication Type :
- Academic Journal
- Accession number :
- 26856224
- Full Text :
- https://doi.org/10.1016/j.ahj.2015.11.012