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Effect of Mirtazapine Treatment on Serum Levels of Brain-Derived Neurotrophic Factor and Tumor Necrosis Factor-α in Patients of Major Depressive Disorder with Severe Depression.
- Source :
-
Pharmacology [Pharmacology] 2016; Vol. 97 (3-4), pp. 184-8. Date of Electronic Publication: 2016 Feb 09. - Publication Year :
- 2016
-
Abstract
- Background: This study evaluated the clinical efficacy of mirtazapine and its effect on serum brain-derived neurotrophic factor (BDNF) and tumor necrosis factor-α (TNF-α) levels in patients of major-depressive disorder (MDD) with severe depression.<br />Methods: Patients (aged 18-60) with MDD diagnosed by DSM-IV criteria, and Hamilton Rating Scale for Depression (HAM-D) score ≥25 were included (n = 30). Mirtazapine was given in the doses of 30 mg/day. All patients were followed up for 12 weeks for the evaluation of clinical efficacy, safety along with serum BDNF and TNF-α levels.<br />Results: HAM-D score at the start of treatment was 30.1 ± 1.92, which significantly (p < 0.05) reduced to 13.47 ± 1.77 at 12 weeks of treatment. In responders, mean serum BDNF levels at the start of treatment were 2.32 ± 0.3 ng/ml, which significantly (p < 0.05) increased to 2.79 ± 0.33 ng/ml at 12 weeks of treatment and mean serum TNF-α levels at the start were 5.18 ± 0.67 pg/ml, which significantly decreased to 4.36 ± 0.72 pg/ml (p < 0.05) at 12 weeks of treatment.<br />Conclusion: Our results suggest that mirtazapine is effective and well tolerated in severely depressed patients and treatment response is associated with an increase in serum BDNF and a decrease in serum TNF-α levels.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Adolescent
Adult
Depression drug therapy
Depressive Disorder, Major drug therapy
Female
Humans
Male
Mianserin pharmacology
Mianserin therapeutic use
Middle Aged
Mirtazapine
Treatment Outcome
Young Adult
Antidepressive Agents, Tricyclic pharmacology
Antidepressive Agents, Tricyclic therapeutic use
Brain-Derived Neurotrophic Factor blood
Depression blood
Depressive Disorder, Major blood
Mianserin analogs & derivatives
Tumor Necrosis Factor-alpha blood
Subjects
Details
- Language :
- English
- ISSN :
- 1423-0313
- Volume :
- 97
- Issue :
- 3-4
- Database :
- MEDLINE
- Journal :
- Pharmacology
- Publication Type :
- Academic Journal
- Accession number :
- 26854819
- Full Text :
- https://doi.org/10.1159/000444220