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Risk Factors Associated with Disease Recurrence in Patients with Stage III/IV Squamous Cell Carcinoma of the Oral Cavity Treated with Surgery and Postoperative Radiotherapy.
- Source :
-
Anticancer research [Anticancer Res] 2016 Feb; Vol. 36 (2), pp. 785-92. - Publication Year :
- 2016
-
Abstract
- Aim: The purpose of the present study was to identify variables associated with high risk of failure in patients with locally advanced squamous cell carcinoma of the oral cavity (SCC-OC).<br />Patients and Methods: This retrospective study included 191 patients with stage III-IVb SCC-OC treated with post-operative radiotherapy (RT) or chemoradiotherapy (CRT) between 1995 and 2013. Disease-free (DFS) and overall survival (OS) were analyzed; variables associated with inferior DFS were identified.<br />Results: Seventy-five patients (39%) recurred. DFS and five-year OS were 52% and 54%, respectively. Poorly differentiated tumors (p=0.03), recurrent tumors (p=0.02) and high nodal ratio (p=0.02) were associated with an increased risk of recurrence. CRT was associated with improved DFS in patients with positive margins and/or extracapsular extension (p=0.021).<br />Conclusion: Tumors that are recurrent, high grade, or have high nodal ratio are at risk of recurrence. Presence of these disease features should be taken into consideration for better risk stratification.<br /> (Copyright© 2016 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Subjects :
- Adult
Aged
Aged, 80 and over
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell pathology
Chemoradiotherapy, Adjuvant
Disease Progression
Disease-Free Survival
Female
Head and Neck Neoplasms mortality
Head and Neck Neoplasms pathology
Humans
Kaplan-Meier Estimate
Lymph Node Excision
Lymphatic Metastasis
Male
Middle Aged
Mouth pathology
Mouth Neoplasms mortality
Mouth Neoplasms pathology
Neoplasm Staging
Neoplasm, Residual
Oral Surgical Procedures mortality
Proportional Hazards Models
Radiotherapy, Adjuvant
Retrospective Studies
Risk Assessment
Risk Factors
Squamous Cell Carcinoma of Head and Neck
Time Factors
Treatment Outcome
Young Adult
Carcinoma, Squamous Cell therapy
Head and Neck Neoplasms therapy
Mouth radiation effects
Mouth surgery
Mouth Neoplasms therapy
Neoplasm Recurrence, Local
Oral Surgical Procedures adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1791-7530
- Volume :
- 36
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Anticancer research
- Publication Type :
- Academic Journal
- Accession number :
- 26851040