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Benchmark Doses Based on Abnormality of WBC or Micronucleus Frequency in Benzene-Exposed Chinese Workers.
- Source :
-
Journal of occupational and environmental medicine [J Occup Environ Med] 2016 Feb; Vol. 58 (2), pp. e39-44. - Publication Year :
- 2016
-
Abstract
- Objectives: The aim of the study was to calculate benchmark dose for chromosomal damage and reduced white blood cell (WBC) associated with exposure to benzene (BZ).<br />Methods: A group of 317 exposed workers and 102 controls were examined for WBC count and genotoxicity by micronucleus (MN) frequency. The cumulative exposure concentration of BZ was calculated by ambient air BZ concentration at worksites in conjunction with job type and associated service duration.<br />Results: MN frequency (Pā<ā0.01) was higher and WBC count was lower (Pā<ā0.01) in exposed workers on average than in the controls. MN frequency was a more sensitive than WBC; workers older than 30 were more susceptible to abnormal MN frequency and WBC count reduction than those younger than 30.<br />Conclusions: Benchmark dose estimates indicated that BZ exposure at levels below the current occupational exposure standard can induce genotoxicity and hematotoxicity.
- Subjects :
- Adult
Case-Control Studies
China
Dose-Response Relationship, Drug
Female
Humans
Leukocyte Count
Leukopenia diagnosis
Male
Micronucleus Tests
Middle Aged
Occupational Diseases diagnosis
Occupational Exposure analysis
Air Pollutants, Occupational toxicity
Benzene toxicity
DNA Damage drug effects
Leukopenia chemically induced
Occupational Diseases chemically induced
Occupational Exposure adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5948
- Volume :
- 58
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of occupational and environmental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 26849270
- Full Text :
- https://doi.org/10.1097/JOM.0000000000000639