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A Newly Characterized Hemoglobin Variant with a High Oxygen Affinity, Hb Fuchu-II, Presenting with Acute Myocardial Infarction.
- Source :
-
Internal medicine (Tokyo, Japan) [Intern Med] 2016; Vol. 55 (3), pp. 285-7. Date of Electronic Publication: 2016 Feb 01. - Publication Year :
- 2016
-
Abstract
- A 65-year-old Japanese man presented with acute myocardial infarction (AMI) and polycythemia. Biochemical studies of the patient's hemoglobin (Hb) and the sequencing of his globin genes revealed that the polycythemia was secondary to a high oxygen affinity Hb variant, Hb Fuchu-II. Hb variants with high oxygen affinity can be an additional thrombotic risk factor in older patients and/or those with other risk factors. The patient was diagnosed with hemoglobinopathy after the development of AMI and exemplifies the importance of recognizing such conditions and of taking appropriate prophylactic interventions.
- Subjects :
- Aged
Chest Pain etiology
Coronary Angiography
Hemoglobins, Abnormal isolation & purification
Humans
Male
Myocardial Infarction complications
Myocardial Infarction drug therapy
Polycythemia complications
Polycythemia drug therapy
Treatment Outcome
Anticoagulants administration & dosage
Aspirin administration & dosage
Chest Pain diagnostic imaging
Hemoglobins, Abnormal metabolism
Myocardial Infarction diagnosis
Oxygen metabolism
Platelet Aggregation Inhibitors administration & dosage
Polycythemia diagnosis
Warfarin administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1349-7235
- Volume :
- 55
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Internal medicine (Tokyo, Japan)
- Publication Type :
- Academic Journal
- Accession number :
- 26831025
- Full Text :
- https://doi.org/10.2169/internalmedicine.55.5311