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A Newly Characterized Hemoglobin Variant with a High Oxygen Affinity, Hb Fuchu-II, Presenting with Acute Myocardial Infarction.

Authors :
Son R
Higuchi T
Mizuno A
Koyamada R
Okada S
Yamashiro Y
Source :
Internal medicine (Tokyo, Japan) [Intern Med] 2016; Vol. 55 (3), pp. 285-7. Date of Electronic Publication: 2016 Feb 01.
Publication Year :
2016

Abstract

A 65-year-old Japanese man presented with acute myocardial infarction (AMI) and polycythemia. Biochemical studies of the patient's hemoglobin (Hb) and the sequencing of his globin genes revealed that the polycythemia was secondary to a high oxygen affinity Hb variant, Hb Fuchu-II. Hb variants with high oxygen affinity can be an additional thrombotic risk factor in older patients and/or those with other risk factors. The patient was diagnosed with hemoglobinopathy after the development of AMI and exemplifies the importance of recognizing such conditions and of taking appropriate prophylactic interventions.

Details

Language :
English
ISSN :
1349-7235
Volume :
55
Issue :
3
Database :
MEDLINE
Journal :
Internal medicine (Tokyo, Japan)
Publication Type :
Academic Journal
Accession number :
26831025
Full Text :
https://doi.org/10.2169/internalmedicine.55.5311