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Paraspinous Lidocaine Injection for Chronic Nonspecific Low Back Pain: A Randomized Controlled Clinical Trial.
- Source :
-
The journal of pain [J Pain] 2016 May; Vol. 17 (5), pp. 569-76. Date of Electronic Publication: 2016 Jan 30. - Publication Year :
- 2016
-
Abstract
- Unlabelled: In this large, sham-controlled, randomized trial, we examined the efficacy of the combination of standard treatment and paraspinous lidocaine injection compared with standard therapy alone in subjects with chronic low back pain. There is little research-based evidence for the routine clinical use of paraspinous lidocaine injection for low back pain. A total of 378 subjects with nonspecific chronic low back pain were randomized to 3 groups: paraspinous lidocaine injection, analgesics, and exercises (group 1, LID-INJ); sham paraspinous lidocaine injection, analgesics, and exercises (group 2, SH-INJ); and analgesics and exercises (group 3, STD-TTR). A blinded rater assessed the study outcomes at 3 time points: baseline, after treatment, and after 3 months of follow-up. There were increased frequency of pain responses and better low back functional scores in the LID-INJ group compared with the SH-INJ and STD-TTR groups. These effects remained at the 3-month follow-up but differed between all 3 groups. There were significant changes in pain threshold immediately after treatment, supporting the effects of this intervention in reducing central sensitization. Paraspinous lidocaine injection therapy is not associated with a higher risk of adverse effects compared with conventional treatment and sham injection. Its effects on hyperalgesia might correlate with changes in central sensitization.<br />Clinical Trial Registration: NCT02387567.<br />Perspective: There are few data to support paraspinous lidocaine injection use in patients with nonspecific chronic low back pain. Our results show that this therapy when combined with standard therapy significantly increases the number of responders versus standard treatment alone. Its effects on hyperalgesia might correlate with a change in central sensitization.<br /> (Copyright © 2016. Published by Elsevier Inc.)
- Subjects :
- Adult
Analysis of Variance
Chronic Pain drug therapy
Disability Evaluation
Exercise Therapy methods
Female
Humans
Male
Middle Aged
Pain Measurement
Retrospective Studies
Anesthetics, Local administration & dosage
Injections, Spinal methods
Lidocaine administration & dosage
Low Back Pain drug therapy
Treatment Outcome
Subjects
Details
- Language :
- English
- ISSN :
- 1528-8447
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- The journal of pain
- Publication Type :
- Academic Journal
- Accession number :
- 26828801
- Full Text :
- https://doi.org/10.1016/j.jpain.2016.01.469