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Prognostic significance of preoperative C-reactive protein: albumin ratio in patients with clear cell renal cell carcinoma.
- Source :
-
International journal of clinical and experimental pathology [Int J Clin Exp Pathol] 2015 Nov 01; Vol. 8 (11), pp. 14893-900. Date of Electronic Publication: 2015 Nov 01 (Print Publication: 2015). - Publication Year :
- 2015
-
Abstract
- We undertook a retrospective analysis to evaluate the C-reactive protein/albumin (CRP/Alb) ratio for its prognostic value in patients with clear cell renal cell carcinoma (CCRCC). The study comprised 406 CCRCC patients undergoing nephrectomy between 2003 and 2012 in our hospital. The correlations among the pretreatment CRP/Alb ratio, clinicopathological parameters, and overall survival (OS) were evaluated. An elevated CRP/Alb ratio was associated with older age at surgery (P=0.007), more advanced TNM stage (P<0.001), more presence of tumor necrosis (P<0.001) and lymphovascular invasion (P<0.001), lower concentration of hemoglobin (P<0.001) and calcium (P=0.005), and shorter OS (P<0.001). The multivariate analysis confirmed that the CRP/Alb ratio independently predicted the OS of patients with CCRCC (P<0.001), the Glasgow Prognostic Score (GPS) (P=0.001) and modified GPS (mGPS) (P=0.019) were independent prognostic factors also. At last, we evaluated the prognostic value of the CRP/Alb ratio compared with the similar inflammation-based prognostic scores GPS and mGPS using the area under the curve (AUC). Although the differences were not statistically significant, the AUC value of the CRP/Alb ratio (continuous, categorical) was higher compared with the GPS and mGPS, except that the AUC value for the CRP/Alb ratio (categorical) at 3 years was lower than that for the GPS. The CRP/Alb ratio could take the place of the GPS and mGPS in terms of predicting prognosis in CCRCC.
- Subjects :
- Adult
Aged
Aged, 80 and over
Area Under Curve
C-Reactive Protein metabolism
Carcinoma, Renal Cell blood
Carcinoma, Renal Cell mortality
Female
Humans
Inflammation blood
Inflammation pathology
Kaplan-Meier Estimate
Kidney Neoplasms blood
Kidney Neoplasms mortality
Male
Middle Aged
Prognosis
Proportional Hazards Models
ROC Curve
Retrospective Studies
Sensitivity and Specificity
Biomarkers, Tumor blood
C-Reactive Protein analysis
Carcinoma, Renal Cell pathology
Kidney Neoplasms pathology
Serum Albumin analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1936-2625
- Volume :
- 8
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- International journal of clinical and experimental pathology
- Publication Type :
- Academic Journal
- Accession number :
- 26823819