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Effect of Antimicrobial Consumption and Production Type on Antibacterial Resistance in the Bovine Respiratory and Digestive Tract.
- Source :
-
PloS one [PLoS One] 2016 Jan 28; Vol. 11 (1), pp. e0146488. Date of Electronic Publication: 2016 Jan 28 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- The aim of this study was to investigate the relationship between antimicrobial use and the occurrence of antimicrobial resistance in the digestive and respiratory tract in three different production systems of food producing animals. A longitudinal study was set up in 25 Belgian bovine herds (10 dairy, 10 beef, and 5 veal herds) for a 2 year monitoring of antimicrobial susceptibilities in E. coli and Pasteurellaceae retrieved from the rectum and the nasal cavity, respectively. During the first year of observation, the antimicrobial use was prospectively recorded on 15 of these farms (5 of each production type) and transformed into the treatment incidences according to the (animal) defined daily dose (TIADD) and (actually) used daily dose (TIUDD). Antimicrobial resistance rates of 4,174 E. coli (all herds) and 474 Pasteurellaceae (beef and veal herds only) isolates for 12 antimicrobial agents demonstrated large differences between intensively reared veal calves (abundant and inconstant) and more extensively reared dairy and beef cattle (sparse and relatively stable). Using linear mixed effect models, a strong relation was found between antimicrobial treatment incidences and resistance profiles of 1,639 E. coli strains (p<0.0001) and 309 Pasteurellaceae (p≤0.012). These results indicate that a high antimicrobial selection pressure, here found to be represented by low dosages of oral prophylactic and therapeutic group medication, converts not only the commensal microbiota from the digestive tract but also the opportunistic pathogenic bacteria in the respiratory tract into reservoirs of multi-resistance.
- Subjects :
- Agriculture
Animals
Anti-Bacterial Agents chemical synthesis
Cattle
Cattle Diseases epidemiology
Cephalosporins chemical synthesis
Drug Resistance, Bacterial
Drug Utilization
Escherichia coli drug effects
Microbial Sensitivity Tests
Prevalence
Prospective Studies
Respiratory Tract Infections drug therapy
Respiratory Tract Infections epidemiology
beta-Lactams chemical synthesis
Anti-Bacterial Agents administration & dosage
Cattle Diseases drug therapy
Cephalosporins administration & dosage
Respiratory Tract Infections veterinary
beta-Lactams administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26820134
- Full Text :
- https://doi.org/10.1371/journal.pone.0146488