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Potent, Selective, and CNS-Penetrant Tetrasubstituted Cyclopropane Class IIa Histone Deacetylase (HDAC) Inhibitors.
- Source :
-
ACS medicinal chemistry letters [ACS Med Chem Lett] 2015 Dec 10; Vol. 7 (1), pp. 34-9. Date of Electronic Publication: 2015 Dec 10 (Print Publication: 2016). - Publication Year :
- 2015
-
Abstract
- Potent and selective class IIa HDAC tetrasubstituted cyclopropane hydroxamic acid inhibitors were identified with high oral bioavailability that exhibited good brain and muscle exposure. Compound 14 displayed suitable properties for assessment of the impact of class IIa HDAC catalytic site inhibition in preclinical disease models.
Details
- Language :
- English
- ISSN :
- 1948-5875
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- ACS medicinal chemistry letters
- Publication Type :
- Academic Journal
- Accession number :
- 26819662
- Full Text :
- https://doi.org/10.1021/acsmedchemlett.5b00302