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Erinacine S, a Rare Sesterterpene from the Mycelia of Hericium erinaceus.
- Source :
-
Journal of natural products [J Nat Prod] 2016 Feb 26; Vol. 79 (2), pp. 438-41. Date of Electronic Publication: 2016 Jan 25. - Publication Year :
- 2016
-
Abstract
- A new sesterterpene, erinacine S, and one cyathane diterpene xyloside, erinacine A, were isolated from the ethanol extract of the mycelia of Hericium erinaceus. Their structures were elucidated by spectroscopic and X-ray analysis. A 30-day oral course of erinacines A and S attenuated Aβ plaque burden in the brains of 5-month-old female APP/PS1 transgenic mice. Moreover, erinacines A and S significantly increased the level of insulin-degrading enzyme in cerebral cortex.
Details
- Language :
- English
- ISSN :
- 1520-6025
- Volume :
- 79
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Journal of natural products
- Publication Type :
- Academic Journal
- Accession number :
- 26807743
- Full Text :
- https://doi.org/10.1021/acs.jnatprod.5b00474