Back to Search
Start Over
Liver fat content is negatively associated with atherosclerotic carotid plaque in type 2 diabetic patients.
- Source :
-
Quantitative imaging in medicine and surgery [Quant Imaging Med Surg] 2015 Dec; Vol. 5 (6), pp. 792-8. - Publication Year :
- 2015
-
Abstract
- Background: Nonalcoholic fatty liver disease (NAFLD) is independently associated with atherosclerosis in nondiabetic individuals. In type 2 diabetic patients, the link between fatty liver and atherosclerosis is less clear. Here, we assessed whether liver fat content evaluated using (1)H-magnetic resonance spectroscopy ((1)H-MRS) was independently associated with prevalent carotid plaque as a marker of atherosclerosis in type 2 diabetic patients.<br />Methods: One hundred and forty-four prospectively enrolled patients with type 2 diabetes underwent liver fat content measurement using (1)H-MRS and carotid plaque assessment using ultrasound. Multiple logistic regressions were used to identify factors associated with carotid plaque.<br />Results: Mean ± SD liver fat content was 9.86±8.12%. Carotid plaque prevalence was 52.1% (75/144). Patients without plaque were younger (P=0.006) and had a smaller visceral fat area (P=0.015), lower reported prevalence of previous cardiovascular events or current statin therapy (P=0.002), and higher liver fat content than those with plaque (P=0.009). By multivariable logistic regression, increased liver fat content independently predicted the absence of carotid plaque [odds ratios (ORs), 0.94; 95% confidence intervals (CIs), 0.89-0.99; P=0.017].<br />Conclusions: Liver fat content measured by (1)H-MRS is higher in type 2 diabetic patients without carotid plaque compared to those with plaque. This study suggests that increased liver fat content could be associated with a relative protection against carotid atherosclerosis in patients with type 2 diabetes mellitus.
Details
- Language :
- English
- ISSN :
- 2223-4292
- Volume :
- 5
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Quantitative imaging in medicine and surgery
- Publication Type :
- Academic Journal
- Accession number :
- 26807360
- Full Text :
- https://doi.org/10.3978/j.issn.2223-4292.2015.12.03