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Acute Methanol Poisoning: Prevalence and Predisposing Factors of Haemorrhagic and Non-Haemorrhagic Brain Lesions.
- Source :
-
Basic & clinical pharmacology & toxicology [Basic Clin Pharmacol Toxicol] 2016 Aug; Vol. 119 (2), pp. 228-38. Date of Electronic Publication: 2016 Feb 10. - Publication Year :
- 2016
-
Abstract
- The purpose was to study the prevalence and predisposing factors of brain lesions in survivors of acute methanol poisoning. Clinical data on 106 patients with methanol poisoning were collected during the Czech mass poisoning outbreak. Of 83 survivors, in 46 (55%) patients, follow-up examinations including magnetic resonance imaging of brain (MR) were performed 3-8 and 24-28 months after discharge from the hospital. Of 46 patients with a median age of 49 (interquartile range, 35-57) years, 24 (52%) patients had a total of 40 abnormal brain findings with haemorrhagic lesions detected in 15 (33%) and non-haemorrhagic lesions found in 9 (19%) patients. The patients with haemorrhagic brain lesions were more acidemic (lower arterial blood pH, higher base deficit) and had higher glycaemia and lactacidaemia on admission than those without haemorrhages (all p < 0.05). Thirteen of 32 (41%) of patients with systemic anticoagulation and 2 of 14 (14%) of patients without it had haemorrhagic lesions (p = 0.080). Bleeding complications during the treatment occurred in 4 of 15 (27%) patients, and 5 of 15 (33%) patients had conditions predisposing to haemorrhage in the group with haemorrhagic lesions. In three cases with a series of computer tomography (CT)/MR performed during hospitalization, the necrotic lesions in the brain remained non-haemorrhagic during hospitalization and haemorrhagic lesions were detected on the follow-up MR examinations only. No association between brain haemorrhages and systemic anticoagulation during dialysis was found: brain haemorrhages might occur in severely poisoned patients treated without systemic anticoagulation, whereas treatment with high doses of heparin might not lead to brain haemorrhages.<br /> (© 2016 Nordic Association for the Publication of BCPT (former Nordic Pharmacological Society).)
- Subjects :
- Adult
Aged
Anticoagulants therapeutic use
Brain pathology
Brain Diseases chemically induced
Brain Diseases drug therapy
Female
Follow-Up Studies
Formates blood
Hemorrhage chemically induced
Hemorrhage drug therapy
Heparin therapeutic use
Hospitalization
Humans
Hydrogen-Ion Concentration
Linear Models
Longitudinal Studies
Magnetic Resonance Imaging
Male
Methanol blood
Middle Aged
Poisoning drug therapy
Prevalence
Retrospective Studies
Risk Factors
Brain drug effects
Brain Diseases epidemiology
Hemorrhage epidemiology
Methanol poisoning
Poisoning epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1742-7843
- Volume :
- 119
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Basic & clinical pharmacology & toxicology
- Publication Type :
- Academic Journal
- Accession number :
- 26806851
- Full Text :
- https://doi.org/10.1111/bcpt.12559