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Trans-Omics: How To Reconstruct Biochemical Networks Across Multiple 'Omic' Layers.
- Source :
-
Trends in biotechnology [Trends Biotechnol] 2016 Apr; Vol. 34 (4), pp. 276-290. Date of Electronic Publication: 2016 Jan 21. - Publication Year :
- 2016
-
Abstract
- We propose 'trans-omic' analysis for reconstructing global biochemical networks across multiple omic layers by use of both multi-omic measurements and computational data integration. We introduce technologies for connecting multi-omic data based on prior knowledge of biochemical interactions and characterize a biochemical trans-omic network by concepts of a static and dynamic nature. We introduce case studies of metabolism-centric trans-omic studies to show how to reconstruct a biochemical trans-omic network by connecting multi-omic data and how to analyze it in terms of the static and dynamic nature. We propose a trans-ome-wide association study (trans-OWAS) connecting phenotypes with trans-omic networks that reflect both genetic and environmental factors, which can characterize several complex lifestyle diseases as breakdowns in the trans-omic system.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3096
- Volume :
- 34
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Trends in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26806111
- Full Text :
- https://doi.org/10.1016/j.tibtech.2015.12.013