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Meta-Analysis of Local Endovascular Therapy for Acute Ischemic Stroke.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2016 Mar; Vol. 27 (3), pp. 307-21.e2. Date of Electronic Publication: 2016 Jan 21. - Publication Year :
- 2016
-
Abstract
- A meta-analysis was performed to assess randomized controlled trials comparing local endovascular therapy (with and without intravenous thrombolysis) versus standard care (intravenous thrombolysis alone when appropriate) for acute ischemic stroke. Local endovascular therapy showed a significant improvement in functional independence versus standard care (odds ratio, 1.779; 95% confidence interval, 1.262-2.507; P < .001). This benefit strengthened further on subgroup analyses of trials in which a majority of cases used stent retrievers, trials with intravenous thrombolysis use in both arms when appropriate, and trials that required preprocedural imaging of all patients. There were no significant differences between arms in terms of mortality, hemicraniectomy, intracranial hemorrhage, and cerebral edema rates (P > .05). In conclusion, in the treatment of acute ischemic stroke, local endovascular therapy leads to improved functional independence compared with standard care.<br /> (Copyright © 2016 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Administration, Intravenous
Brain Ischemia diagnosis
Brain Ischemia mortality
Brain Ischemia physiopathology
Cerebrovascular Circulation
Disability Evaluation
Fibrinolytic Agents adverse effects
Humans
Odds Ratio
Randomized Controlled Trials as Topic
Recovery of Function
Risk Factors
Stroke diagnosis
Stroke mortality
Stroke physiopathology
Treatment Outcome
Brain Ischemia therapy
Endovascular Procedures adverse effects
Endovascular Procedures mortality
Fibrinolytic Agents administration & dosage
Stroke therapy
Thrombolytic Therapy adverse effects
Thrombolytic Therapy mortality
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 27
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 26803573
- Full Text :
- https://doi.org/10.1016/j.jvir.2015.11.053