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Heavy metal and trace element concentrations in blood and follicular fluid affect ART outcome.
- Source :
-
European journal of obstetrics, gynecology, and reproductive biology [Eur J Obstet Gynecol Reprod Biol] 2016 Mar; Vol. 198, pp. 73-77. Date of Electronic Publication: 2016 Jan 11. - Publication Year :
- 2016
-
Abstract
- Objectives: To assess the effects of heavy metal and trace element concentrations in blood and follicular fluid on assisted reproductive technology cycle outcome.<br />Study Design: A prospective study was conducted between January 2012 and July 2012 in a university hospital infertility clinic. One hundred and one patients with unexplained infertility who underwent intracytoplasmic sperm injection using GnRH-antagonist protocol were recruited. Concentrations of four toxic metals (Cd, Pb, Hg, As) and three trace elements (Cu, Zn, Fe) were measured both in blood and follicular fluid specimens. Patients were evaluated in two groups; the study group consisted of patients with ongoing pregnancy (n=20) and the reference group consisted of patients experienced assisted reproductive technology failure, miscarriage or biochemical pregnancy (n=81).<br />Results: Demographics and cycle parameters were comparable between the groups except for median number of day 3 Grade A embryos. Statistically significant negative correlations were found between blood Pb levels and number of MII oocytes, implantation, clinical pregnancy and ongoing pregnancy rates. Results of the log binomial regression revealed 2.2% lower risk for ongoing pregnancy for each 1μg/dL higher blood Pb concentration while holding the other variables in the model constant (RR 0.978; 95% CI 0.956-0.998; P=.041). Also, the results revealed 71.9% lower risk for ongoing pregnancy for each 1μg/dL higher follicular fluid Cu concentration while holding the other variables in the model constant (RR 0.288; 95% CI 0.085-0.92; P=.039).<br />Conclusion: Blood concentrations of Pb and follicular fluid concentrations of Cu seem to have significant impacts on assisted reproductive technology cycle outcome.<br /> (Copyright © 2016 Elsevier Ireland Ltd. All rights reserved.)
- Subjects :
- Adult
Female
Fertilization in Vitro
Humans
Metals, Heavy blood
Pregnancy
Pregnancy Outcome
Pregnancy Rate
Prospective Studies
Sperm Injections, Intracytoplasmic
Trace Elements blood
Treatment Outcome
Young Adult
Abortion, Spontaneous blood
Follicular Fluid chemistry
Metals, Heavy analysis
Reproductive Techniques, Assisted
Trace Elements analysis
Subjects
Details
- Language :
- English
- ISSN :
- 1872-7654
- Volume :
- 198
- Database :
- MEDLINE
- Journal :
- European journal of obstetrics, gynecology, and reproductive biology
- Publication Type :
- Academic Journal
- Accession number :
- 26802253
- Full Text :
- https://doi.org/10.1016/j.ejogrb.2016.01.001