Back to Search
Start Over
Gastroesophageal Reflux Disease in Time Covering Eradication for All Patients Infected with Helicobacter pylori in Japan.
- Source :
-
Digestion [Digestion] 2016; Vol. 93 (1), pp. 24-31. Date of Electronic Publication: 2016 Jan 14. - Publication Year :
- 2016
-
Abstract
- Background: The prevalence of gastroesophageal reflux disease (GERD) has increased in Japan since the end of the 20th century due to changes in environmental factors, such as a decreased infection rate of Helicobacter pylori and increased ability of acid secretion in the Japanese population. In 2013, the Japanese health insurance system started to cover eradication treatment for all patients infected with H. pylori to prevent gastric cancer, suggesting we may soon be able to completely eradicate this infection in Japan. Re-clarification of the clinical characteristics of GERD in Japan is therefore required in time covering the eradication for all patients infected with H. pylori.<br />Summary: In Japan, more than half of GERD patients exhibit non-erosive reflux disease, and a majority of erosive esophagitis (RE) cases have mild severity of GERD (Los Angeles classification of grades A and B). The prevalence of RE in H. pylori-positive patients is relatively low (4.1%) compared to the general Japanese population (7.6-10.6%). In multivariate analysis to evaluate a risk of RE development, a risk in H. pylori-positive patients is elevated in those with mild gastric mucosal atrophy (C-I and C-II according to the Kimura-Takemoto classification, OR 12.14, 95% CI 1.28-115.26, p = 0.03) or with hiatal hernia (OR 5.24, 95% CI 1.80-15.22, p < 0.01). Here, we provide a comprehensive review of GERD in Japan, including associations between GERD and H. pylori infection, low-dose-aspirin-induced GERD, and pharmacological treatment for GERD.<br />Key Messages: The recent decrease in the rate of H. pylori infection and increase in the proportion of elderly persons might have increased the prevalence of GERD in Japan.<br /> (© 2016 S. Karger AG, Basel.)
- Subjects :
- Age Factors
Aged
Barrett Esophagus epidemiology
Esophagitis, Peptic drug therapy
Esophagitis, Peptic pathology
Female
Gastroesophageal Reflux drug therapy
Gastroesophageal Reflux pathology
Helicobacter Infections drug therapy
Helicobacter Infections pathology
Helicobacter pylori
Hernia, Hiatal epidemiology
Humans
Japan epidemiology
Male
Middle Aged
Multivariate Analysis
Peptic Ulcer epidemiology
Prevalence
Risk Factors
Sex Factors
Esophagitis, Peptic epidemiology
Gastric Mucosa pathology
Gastroesophageal Reflux epidemiology
Helicobacter Infections epidemiology
Subjects
Details
- Language :
- English
- ISSN :
- 1421-9867
- Volume :
- 93
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Digestion
- Publication Type :
- Academic Journal
- Accession number :
- 26789391
- Full Text :
- https://doi.org/10.1159/000441741