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Induced production of cytochalasans in co-culture of marine fungus Aspergillus flavipes and actinomycete Streptomyces sp.
- Source :
-
Natural product research [Nat Prod Res] 2016 Aug; Vol. 30 (15), pp. 1718-23. Date of Electronic Publication: 2016 Jan 19. - Publication Year :
- 2016
-
Abstract
- Abstarct Secondary metabolites profiles of co-culture of Aspergillus flavipes and Streptomyces sp. that isolated from the same habitat showed an induced production of a series of cytochalasans (five aspochalasins and rosellichalasin, determined by MS and NMR analysis). These cytochalasans were found to be produced by A. flavipes in LC-MS comparison analysis, and biological activity assays revealed that they were able to cause cytotoxic effects against Streptomyces sp. within a wide range of concentrations without causing any effect to the producer A. flavipes, which favoured the producer in competition. Further induction mechanism study applying membrane-separated culture and morphology study with scanning electron microscopy (SEM) suggested that the successful induction of active secondary metabolites required microbial physical contact.
Details
- Language :
- English
- ISSN :
- 1478-6427
- Volume :
- 30
- Issue :
- 15
- Database :
- MEDLINE
- Journal :
- Natural product research
- Publication Type :
- Academic Journal
- Accession number :
- 26783945
- Full Text :
- https://doi.org/10.1080/14786419.2015.1136910