Back to Search
Start Over
Meta-analysis of STAT4 and IFIH1 polymorphisms in type 1 diabetes mellitus patients with autoimmune polyglandular syndrome type III.
- Source :
-
Genetics and molecular research : GMR [Genet Mol Res] 2015 Dec 22; Vol. 14 (4), pp. 17730-8. Date of Electronic Publication: 2015 Dec 22. - Publication Year :
- 2015
-
Abstract
- Type 1 diabetes mellitus (T1D) is an organ-specific autoimmune disease characterized by T-cell mediated self-destruction of insulin-producing β cells in the pancreas. T1D patients are prone to develop other glandular autoimmune disorders, such as autoimmune thyroid disease that occurs simultaneously with autoimmune polyglandular syndrome type III (APSIII). Signal transducer and activator of transcription 4 (STAT4) is a well-known regulator of proinflammatory cytokines, and interferon-induced with helicase C domain 1 (IFIH1) is activated in the interferon type I response. Both genes have been examined separately in autoimmune diseases and, in this study, we assessed their joint role in T1D and APSIII. We conducted a case-control study, enrolling 173 T1D patients and 191 healthy controls from northeastern Brazil, to assess the distribution of the rs7574865 and rs3024839 SNPs in STAT4 and the rs3747517 and rs1990760 SNPs in IFIH1 in T1D and APSIII patients. Additionally, we conducted a meta-analysis with the rs7574865 SNP in STAT4 (1392 T1D patients and 1629 controls) and the rs1990760 SNP in IFIH1 (25092 T1D patients and 28544 controls) to examine their association with T1D. Distribution of STAT4 and IFIH1 allelic frequencies did not show statistically significant differences between T1D patients and controls in our study population; however, the meta-analysis indicated that SNPs in STAT4 and IFIH1 are associated with T1D worldwide. Our findings indicate that although STAT4 and IFIH1 SNPs are not associated with T1D in a Brazilian population, they might play a role in susceptibility to T1D on a larger worldwide scale.
- Subjects :
- Adolescent
Adult
Aged
Child
Child, Preschool
Diabetes Mellitus, Type 1 complications
Diabetes Mellitus, Type 1 pathology
Female
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Infant
Infant, Newborn
Insulin-Secreting Cells metabolism
Insulin-Secreting Cells pathology
Interferon-Induced Helicase, IFIH1
Male
Middle Aged
Polyendocrinopathies, Autoimmune complications
Polyendocrinopathies, Autoimmune pathology
Polymorphism, Single Nucleotide
Signal Transduction genetics
DEAD-box RNA Helicases genetics
Diabetes Mellitus, Type 1 genetics
Polyendocrinopathies, Autoimmune genetics
STAT4 Transcription Factor genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1676-5680
- Volume :
- 14
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Genetics and molecular research : GMR
- Publication Type :
- Academic Journal
- Accession number :
- 26782418
- Full Text :
- https://doi.org/10.4238/2015.December.21.46