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Hepatitis C reinfection after sustained virological response.
- Source :
-
Journal of hepatology [J Hepatol] 2016 May; Vol. 64 (5), pp. 1020-1026. Date of Electronic Publication: 2016 Jan 11. - Publication Year :
- 2016
-
Abstract
- Background & Aims: On-going risk behaviour can lead to hepatitis C virus (HCV) reinfection following successful treatment. We aimed to assess the incidence of persistent HCV reinfection in a population of people who inject drugs (PWID) who had achieved sustained virological response (SVR) seven years earlier.<br />Methods: In 2004-2006 we conducted a multicentre treatment trial comprising HCV genotype 2 or 3 patients in Sweden, Norway and Denmark (NORTH-C). Six months of abstinence from injecting drug use (IDU) was required before treatment. All Norwegian patients who had obtained SVR (n=161) were eligible for participation in this long-term follow-up study assessing virological and behavioural characteristics.<br />Results: Follow-up data were available in 138 of 161 (86%) individuals. Persistent reinfection was identified in 10 of 94 (11%) individuals with a history of IDU prior to treatment (incidence rate 1.7/100 person-years (PY); 95% CI 0.8-3.1) and in 10 of 37 (27%) individuals who had relapsed to IDU after treatment (incidence rate 4.9/100 PY; 95% CI 2.3-8.9). Although relapse to IDU perfectly predicted reinfection, no baseline factor was associated with reinfection. Relapse to IDU was associated with age <30 years (vs. ⩾40 years) at treatment (adjusted odds ratio [aOR] 7.03; 95% CI 1.78-27.8) and low education level (aOR 3.64; 95% CI 1.44-9.18).<br />Conclusions: Over time, persistent HCV reinfection was common among individuals who had relapsed to IDU after treatment. Reinfection should be systematically addressed and prevented when providing HCV care for PWID.<br /> (Copyright © 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.)
- Subjects :
- Adult
Denmark epidemiology
Female
Follow-Up Studies
Hepatitis C, Chronic epidemiology
Hepatitis C, Chronic virology
Humans
Incidence
Male
Middle Aged
Norway epidemiology
Odds Ratio
Recurrence
Retrospective Studies
Risk Factors
Sweden epidemiology
Antiviral Agents therapeutic use
Hepacivirus genetics
Hepatitis C, Chronic drug therapy
RNA, Viral genetics
Sustained Virologic Response
Viral Load drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0641
- Volume :
- 64
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Journal of hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 26780289
- Full Text :
- https://doi.org/10.1016/j.jhep.2016.01.001