Changes in four plasma adipokines before and after sleep in OSAS patients.

Objectives: This study aimed to investigate whether plasma levels of four adipokines (chemerin, macrophage migratory inhibitory factor [MIF], visceral adipose tissue-derived serine protease inhibitor [vaspin] and chemokine CXCL5) are associated with the presence of obstructive sleep apnea syndrome (OSAS) in patients.
Methods: A total of 58 male patients with OSAS and 16 healthy male subjects were enrolled in this study.
Results: Four plasma adipokines (chemerin, MIF, vaspin and chemokine CXCL5) were significantly higher (P < 0.05) in severe OSAS patients than in the control group after polysomnography. Plasma levels of these four adipokines were higher (P < 0.05) after sleep than before sleep. These levels were also associated with anthropometric measurements for BMI, neck circumference, body fat percentage, sleep parameters including the apnea/hypopnea index (AHI) and minimum SaO ₂ %. Multiple regression analyses showed that BMI, AHI and mean SaO ₂ % were major factors affecting the four plasma adipokine levels in OSAS patients.
Conclusions: Plasma chemerin, MIF, vaspin and chemokine CXCL5 levels were severely elevated with OSAS, and were also connected with obesity.
(© 2016 John Wiley & Sons Ltd.)