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β-Cyclodextrin preventing protein aggregation in foam fractionation of bovine serum albumin.
- Source :
-
Journal of biotechnology [J Biotechnol] 2016 Feb 20; Vol. 220, pp. 33-4. Date of Electronic Publication: 2016 Jan 14. - Publication Year :
- 2016
-
Abstract
- In this work, β-cyclodextrin was developed to prevent protein aggregation in foam fractionation using bovine serum albumin (BSA) as a model protein. The role of β-cyclodextrin in preventing the aggregation of BSA induced by the gas-liquid interface was studied at the molecular level. The results indicate that by holding the exposed phenylalanine residues in its hydrophobic cavity, β-cyclodextrin effectively prevented the aggregation of BSA induced by the gas-liquid interface in foam fractionation. Furthermore, β-cyclodextrin could be effectively separated from BSA in the foamate due to their weak association.<br /> (Copyright © 2016 Elsevier B.V. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1873-4863
- Volume :
- 220
- Database :
- MEDLINE
- Journal :
- Journal of biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 26778542
- Full Text :
- https://doi.org/10.1016/j.jbiotec.2016.01.007