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Routine invasive strategy in acute coronary syndrome patients with renal dysfunction. Results of the ARIAM-SEMICYUC registry.

Authors :
Latour-Pérez J
Gómez-Tello V
de-Miguel-Balsa E
Llamas-Álvarez A
Carrillo-López A
Sánchez-Román JA
Ruíz-Ruíz J
Martín-Rodríguez MC
Fernández-González CJ
Fernández-Lozano JA
Picazos Vicente C
Source :
Medicina intensiva [Med Intensiva] 2016 Jun-Jul; Vol. 40 (5), pp. 280-8. Date of Electronic Publication: 2016 Jan 14.
Publication Year :
2016

Abstract

Objective: To evaluate the use and effectiveness of a routine invasive strategy (RIS) in patients with acute coronary syndrome without persistent ST-segment elevation with renal dysfunction in the real world scenario.<br />Methods: A retrospective cohort study based on the ARIAM-SEMICYUC Registry (2011-2014) was carried out. Renal dysfunction was defined as GFR (Cockroft-Gault)<60ml/min (moderate dysfunction) or<30ml/min (severe dysfunction). Patients in which early angiography (<72h) was performed due to cardiogenic shock or recurrent myocardial ischemia were excluded. The primary endpoint was hospital mortality. Confounding factors were controlled using propensity score analysis.<br />Results: A total of 4,279 patients were analyzed, of which 26% had moderate renal dysfunction and 5% severe dysfunction. Patients with renal dysfunction had greater severity and comorbidity, higher hospital mortality (8.6 vs. 1.8%), and lesser use of the RIS (40 vs. 52%). The adjusted OR for mortality in patients without/with renal dysfunction were 0.38 (95% confidence interval [95%CI] 0.17 to 0.81) and 0.52 (95%CI 0.32 to 0.87), respectively (interaction P-value=.4779). The impact (adjusted risk difference) of RIS was higher in the group with renal dysfunction (-5.1%, 95%CI -8.1 to -2.1 vs. -1.6%, 95%CI -2.6 to -0.6; interaction P-value=.0335). No significant interaction was detected for the other endpoints considered (ICU mortality, 30-day mortality, myocardial infarction, acute renal failure or moderate/severe bleeding).<br />Conclusions: The results suggest that the effectiveness of IRS is similar in patients with normal or abnormal renal function, and alert to the under-utilization of this strategy in such patients.<br /> (Copyright © 2015 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.)

Details

Language :
English; Spanish; Castilian
ISSN :
1578-6749
Volume :
40
Issue :
5
Database :
MEDLINE
Journal :
Medicina intensiva
Publication Type :
Academic Journal
Accession number :
26777736
Full Text :
https://doi.org/10.1016/j.medin.2015.09.008