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Long-term toxicity study on genetically modified corn with cry1Ac gene in a Wuzhishan miniature pig model.
- Source :
-
Journal of the science of food and agriculture [J Sci Food Agric] 2016 Sep; Vol. 96 (12), pp. 4207-14. Date of Electronic Publication: 2016 Feb 17. - Publication Year :
- 2016
-
Abstract
- Background: The objective of the present study was to investigate the chronic effect of transgenic maize lines by the insertion of the cry1Ac gene from Bacillus thuringiensis (Bt) on the growth performance, immune response and health using a Wuzhishan miniature pig model through a 196-day feeding study.<br />Results: Based on the gender and weight, 72 Wuzhishan miniature pigs were randomly assigned one of the diets containing 65% non-transgenic isogenic corn or Bt corn at three stages of growth (day 0-69, 70-134 and 135-196). The potential toxicological effects of transgenic corn on pigs were explored. No difference between the diet treatments for growth performance and haematology parameters at any stages of growth. Although subtle differences in serum content of alanine aminotransferase, relative kidney weight and some immune response were observed between the Bt group and isogenic group, they were not considered as diet treatment-related.<br />Conclusion: Long-term feeding Bt corn carrying cry1Ac genes to Wuzhishan miniature pigs did not indicate adverse effects on the growth, immune response and health indicators at any stages of growth. © 2016 Society of Chemical Industry.<br /> (© 2016 Society of Chemical Industry.)
- Subjects :
- Animals
Bacillus thuringiensis genetics
Bacillus thuringiensis Toxins
Cell Line
Female
Kidney anatomy & histology
Kidney pathology
Male
Models, Animal
Plants, Genetically Modified chemistry
Swine
Swine, Miniature blood
Swine, Miniature immunology
T-Lymphocytes cytology
T-Lymphocytes immunology
Toxicity Tests
Weight Gain
Zea mays chemistry
Animal Feed adverse effects
Bacterial Proteins genetics
Endotoxins genetics
Hemolysin Proteins genetics
Plants, Genetically Modified adverse effects
Plants, Genetically Modified genetics
Swine, Miniature growth & development
Zea mays adverse effects
Zea mays genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0010
- Volume :
- 96
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of the science of food and agriculture
- Publication Type :
- Academic Journal
- Accession number :
- 26777397
- Full Text :
- https://doi.org/10.1002/jsfa.7624