Back to Search
Start Over
The Changing Profile of Helicobacter pylori Antibiotic Resistance in Singapore: A 15-Year Study.
- Source :
-
Helicobacter [Helicobacter] 2016 Aug; Vol. 21 (4), pp. 261-5. Date of Electronic Publication: 2016 Jan 15. - Publication Year :
- 2016
-
Abstract
- Background: Antibiotic resistance is an important cause of H. pylori treatment failure. This study aimed to examine the change in H. pylori antibiotic resistance profile in Singapore over the course of 15 years.<br />Materials and Methods: The study period was from 2000 to 2014. Gastric mucosal biopsies obtained from H. pylori-positive patients were cultured. Antibiotic susceptibility to metronidazole, clarithromycin, levofloxacin, tetracycline, and amoxicillin was tested. The change in resistance rates over time was analyzed.<br />Results: A total of 708 H. pylori isolates were cultured. There was a significant increase in resistance rates for metronidazole (2000-2002: 24.8%; 2012-2014: 48.2%; p < .001), clarithromycin (2000-2002: 7.9%; 2012-2014: 17.1%; p = .022), and levofloxacin (2000-2002: 5%; 2012-2014: 14.7%; p = .007). The resistance rates for tetracycline (2000-2002: 5%; 2012-2014: 7.6%) and amoxicillin (2000-2002: 3%; 2012-2014: 4.4%) remained stable. Increase in dual (2000-2002: 6.9%; 2012-2014: 9.4%; p = .479) and triple antibiotic resistance rates (2000-2002: 0; 2012-2014: 7.6%; p < .001) were observed. Overall, the most common dual and triple resistance patterns were metronidazole/clarithromycin (4.4%) and metronidazole/clarithromycin/levofloxacin (1.8%), respectively.<br />Conclusions: Over 15 years, H. pylori resistance rates to metronidazole, clarithromycin and levofloxacin had increased. There was increased resistance to multiple antibiotics.<br /> (© 2016 John Wiley & Sons Ltd.)
- Subjects :
- Adult
Aged
Biopsy
Female
Gastric Mucosa microbiology
Helicobacter Infections epidemiology
Helicobacter pylori isolation & purification
Humans
Male
Middle Aged
Prevalence
Singapore epidemiology
Time Factors
Young Adult
Anti-Bacterial Agents pharmacology
Drug Resistance, Bacterial
Helicobacter Infections microbiology
Helicobacter pylori drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1523-5378
- Volume :
- 21
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Helicobacter
- Publication Type :
- Academic Journal
- Accession number :
- 26774006
- Full Text :
- https://doi.org/10.1111/hel.12291