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T2 mapping at 7T MRI can quantitatively assess intramyocardial hemorrhage in rats with acute reperfused myocardial infarction in vivo.
- Source :
-
Journal of magnetic resonance imaging : JMRI [J Magn Reson Imaging] 2016 Jul; Vol. 44 (1), pp. 194-203. Date of Electronic Publication: 2016 Jan 13. - Publication Year :
- 2016
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Abstract
- Purpose: To investigate T2 mapping at 7T magnetic resonance imaging (MRI) for the detection and quantification of reperfused intramyocardial hemorrhage (IMH) in a rat model.<br />Materials and Methods: Myocardial infarction (MI) was induced in 25 female rats. Rats were scanned at a 7T MRI 48 hours after reperfusion, using T2 mapping and late gadolinium enhancement imaging. Gross sections of the left ventricular myocardium and corresponding hematoxylin and eosin staining were assessed for IMH. T2 mapping images were matched with the gross sections. The IMH volume, expressed as a percentage of the left ventricular myocardial volume, of each heart determined by T2 mapping was compared with that calculated by pathological gross examination.<br />Results: Six rats died. In all, 97 gross sections of the left ventricular myocardium from the 19 rats were matched with T2 mapping images. IMH occurred pathologically in 68 gross sections, which was detected as hypointense cores by T2 mapping in 63 images (93% sensitivity). Three T2 mapping images with hypointense cores showed no hemorrhage on pathological sections (90% specificity). The positive and negative predictive values of hemorrhage on T2 mapping were 95% and 84%, respectively. In terms of the IMH volume, there was no significant difference between T2 mapping and pathological gross measurements (4.8 ± 2.4% vs. 5.3 ± 3.2%; P = 0.11).<br />Conclusion: T2 mapping at 7T MRI can reliably detect and quantify IMH in rats in vivo. This may be useful as a noninvasive quantitative approach to investigating the mechanisms and evolution of MI and reperfusion injury. J. Magn. Reson. Imaging 2016;44:194-203.<br /> (© 2016 Wiley Periodicals, Inc.)
- Subjects :
- Animals
Female
Image Enhancement methods
Rats
Rats, Sprague-Dawley
Reproducibility of Results
Sensitivity and Specificity
Algorithms
Hemorrhage diagnostic imaging
Hemorrhage etiology
Image Interpretation, Computer-Assisted methods
Myocardial Reperfusion Injury complications
Myocardial Reperfusion Injury diagnostic imaging
Subjects
Details
- Language :
- English
- ISSN :
- 1522-2586
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Journal of magnetic resonance imaging : JMRI
- Publication Type :
- Academic Journal
- Accession number :
- 26762612
- Full Text :
- https://doi.org/10.1002/jmri.25145