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Antithrombotic and antiplatelet activities of pelargonidin in vivo and in vitro.
- Source :
-
Archives of pharmacal research [Arch Pharm Res] 2016 Mar; Vol. 39 (3), pp. 398-408. Date of Electronic Publication: 2016 Jan 13. - Publication Year :
- 2016
-
Abstract
- Pelargonidin is a well-known red pigment found in plants, and has been reported as having important biological activities that are potentially beneficial for human health. However, the possible roles of pelargonidin as an anticoagulant and the underlying mechanism have not yet been elucidated. We tested the effect of pelargonidin and its glucoside-conjugated form, pelargonidin-3-glucoside, on the clotting times, such as activated partial thromboplastin time (aPTT) and prothrombin time (PT), and the activities and productions of thrombin and activated factor X (FXa). Furthermore, the effects of pelargonidin on the fibrin polymerization, platelet aggregation, and the ratio of plasminogen activator inhibitor-1 (PAI-1) to tissue plasminogen activator were determined. Pelargonidin, but not pelargonidin-3-glucoside, prolonged the aPTT and PT, and inhibited the activity and production of thrombin and FXa in human umbilical vein endothelial cells. Furthermore, pelargonidin inhibited thrombin-catalyzed fibrin polymerization and platelet aggregation and elicited anticoagulant effects in mice. In addition, pelargonidin significantly reduced PAI-1 to t-PA ratio. Collectively, these results indicate that the anthocyanin pelargonidin possesses antithrombotic activity, and can be beneficial in preventing thrombus formation, thus improving blood circulation.
- Subjects :
- Animals
Anticoagulants pharmacology
Bleeding Time
Cell Survival drug effects
Cells, Cultured
Factor Xa biosynthesis
Fibrin drug effects
Fibrin metabolism
Humans
Male
Mice
Plasminogen Activator Inhibitor 1 metabolism
Thrombin drug effects
Thrombin metabolism
Tissue Plasminogen Activator metabolism
Anthocyanins pharmacology
Anticoagulants administration & dosage
Blood Coagulation drug effects
Platelet Aggregation drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1976-3786
- Volume :
- 39
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Archives of pharmacal research
- Publication Type :
- Academic Journal
- Accession number :
- 26762345
- Full Text :
- https://doi.org/10.1007/s12272-016-0708-x