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Novel polymorphisms in caspase-8 are associated with breast cancer risk in the California Teachers Study.
- Source :
-
BMC cancer [BMC Cancer] 2016 Jan 12; Vol. 16, pp. 14. Date of Electronic Publication: 2016 Jan 12. - Publication Year :
- 2016
-
Abstract
- Background: The ability of tamoxifen and raloxifene to decrease breast cancer risk varies among different breast cancer subtypes. It is important to determine one's subtype-specific breast cancer risk when considering chemoprevention. A number of single nucleotide polymorphisms (SNPs), including one in caspase-8 (CASP8), have been previously associated with risk of developing breast cancer. Because caspase-8 is an important protein involved in receptor-mediated apoptosis whose activity is affected by estrogen, we hypothesized that additional SNPs in CASP8 could be associated with breast cancer risk, perhaps in a subtype-specific manner.<br />Methods: Twelve tagging SNPs of CASP8 were analyzed in a nested case control study (1,353 cases and 1,384 controls) of non-Hispanic white women participating in the California Teachers Study. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated for each SNP using all, estrogen receptor (ER)-positive, ER-negative, human epidermal growth factor receptor 2 (HER2)-positive, and HER2-negative breast cancers as separate outcomes.<br />Results: Several SNPs were associated with all, ER-positive, and HER2-positive breast cancers; however, after correcting for multiple comparisons (i.e., p < 0.0008), only rs2293554 was statistically significantly associated with HER2-positive breast cancer (OR = 1.98, 95% CI 1.34-2.92, uncorrected p = 0.0005).<br />Conclusions: While our results for CASP8 SNPs should be validated in other cohorts with subtype-specific information, we conclude that some SNPs in CASP8 are associated with subtype-specific breast cancer risk. This study contributes to our understanding of CASP8 SNPs and breast cancer risk by subtype.
- Subjects :
- Adult
Breast Neoplasms pathology
California
Female
Genotype
Humans
Middle Aged
Polymorphism, Single Nucleotide
Receptor, ErbB-2 genetics
Receptors, Estrogen genetics
Receptors, Progesterone genetics
Risk Factors
Breast Neoplasms genetics
Caspase 8 genetics
Genetic Association Studies
Genetic Predisposition to Disease
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2407
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- BMC cancer
- Publication Type :
- Academic Journal
- Accession number :
- 26758508
- Full Text :
- https://doi.org/10.1186/s12885-015-2036-9