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Essential Contribution of CD4+ T Cells to Antigen-Induced Nasal Hyperresponsiveness in Experimental Allergic Rhinitis.
- Source :
-
PloS one [PLoS One] 2016 Jan 11; Vol. 11 (1), pp. e0146686. Date of Electronic Publication: 2016 Jan 11 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Nasal hyperresponsiveness (NHR) is a characteristic feature of allergic rhinitis (AR); however, the pathogenesis of NHR is not fully understood. In this study, during the establishment of an experimental AR model using ovalbumin-immunized and -challenged mice, augmentation of the sneezing reaction in response to nonspecific proteins as well as a chemical stimulant was detected. Whether NHR is independent of mast cells and eosinophils was determined by using mast cell- and eosinophil-deficient mice. NHR was suppressed by treatment with anti-CD4 antibody, suggesting the pivotal contribution of CD4+ T cells. Furthermore, antigen challenge to mice to which in vitro-differentiated Th1, Th2, and Th17 cells but not naïve CD4+ T cells had been adoptively transferred led to the development of equivalent NHR. Since antigen-specific IgE and IgG were not produced in these mice and since antigen-specific IgE-transgenic mice did not develop NHR even upon antigen challenge, humoral immunity would be dispensable for NHR. CD4+ T cells play a crucial role in the pathogenesis of AR via induction of NHR, independent of IgE-, mast cell-, and eosinophil-mediated responses.
- Subjects :
- Animals
Antibodies, Monoclonal pharmacology
CD4-Positive T-Lymphocytes drug effects
Eosinophils cytology
Eosinophils drug effects
Female
Immunization
Immunoglobulin E metabolism
Mast Cells cytology
Mast Cells drug effects
Mice, Inbred BALB C
Antigens immunology
CD4-Positive T-Lymphocytes immunology
Nose pathology
Respiratory Hypersensitivity complications
Respiratory Hypersensitivity immunology
Rhinitis, Allergic complications
Rhinitis, Allergic immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26752722
- Full Text :
- https://doi.org/10.1371/journal.pone.0146686