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Stakeholders' Perspectives on Preclinical Testing for Alzheimer's Disease.
- Source :
-
The Journal of clinical ethics [J Clin Ethics] 2015 Winter; Vol. 26 (4), pp. 297-305. - Publication Year :
- 2015
-
Abstract
- Background and Aims: Progress towards validating amyloid beta as an early indicator of Alzheimer's disease (AD) heightens the need for evaluation of stakeholders' perspectives of the benefits and harms of preclinical testing in asymptomatic individuals.<br />Methods: Investigators conducted and analyzed 14 semi-structured interviews with family members of patients diagnosed with AD.<br />Results: Participants reported benefits, including the potential to seek treatment, make lifestyle changes, and prepare for cognitive impairment. Participants identified harms, including social harms, adverse life decisions, and psychological harms. Nine participants reported either a "positive global perspective" or a "positive global perspective (qualified)."<br />Conclusion: Results from this study characterized stakeholders' perspectives on the potential benefits and harms of clinical use of preclinical testing for AD. Investigators used data from this study to develop a framework that contributes to ongoing discussions that will evaluate widespread adoption of preclinical testing and will inform future research.<br /> (Copyright 2015 The Journal of Clinical Ethics. All rights reserved.)
- Subjects :
- Activities of Daily Living
Adult
Aged
Aged, 80 and over
Alzheimer Disease cerebrospinal fluid
Alzheimer Disease diagnostic imaging
Alzheimer Disease psychology
Amyloid beta-Peptides cerebrospinal fluid
Biomarkers cerebrospinal fluid
Disease Progression
Female
Humans
Interviews as Topic
Male
Middle Aged
Positron-Emission Tomography
Risk Reduction Behavior
Alzheimer Disease diagnosis
Decision Making
Family psychology
Health Behavior
Mass Screening adverse effects
Mass Screening ethics
Mass Screening psychology
Temperament
Subjects
Details
- Language :
- English
- ISSN :
- 1046-7890
- Volume :
- 26
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- The Journal of clinical ethics
- Publication Type :
- Academic Journal
- Accession number :
- 26752383