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Internal exposure levels of typical POPs and their associations with childhood asthma in Shanghai, China.
- Source :
-
Environmental research [Environ Res] 2016 Apr; Vol. 146, pp. 125-35. Date of Electronic Publication: 2015 Dec 31. - Publication Year :
- 2016
-
Abstract
- Polybrominated diphenyl ethers (PBDEs), polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) are common persistent organic pollutants (POPs) that may be associated with childhood asthma. The concentrations of PBDEs, PCBs and OCPs were analyzed in pooled serum samples from both asthmatic and non-asthmatic children. The differences in the internal exposure levels between the case and control groups were tested (p value <0.0012). The associations between the internal exposure concentrations of the POPs and childhood asthma were estimated based on the odds ratios (ORs) calculated using logistic regression models. There were significant differences in three PBDEs, 26 PCBs and seven OCPs between the two groups, with significantly higher levels in the cases. The multiple logistic regression models demonstrated that the internal exposure concentrations of a number of the POPs (23 PCBs, p,p'-DDE and α-HCH) were positively associated with childhood asthma. Some synergistic effects were observed when the children were co-exposed to the chemicals. BDE-209 was positively associated with asthma aggravation. This study indicates the potential relationships between the internal exposure concentrations of particular POPs and the development of childhood asthma.<br /> (Copyright © 2015 Elsevier Inc. All rights reserved.)
- Subjects :
- Asthma chemically induced
Case-Control Studies
Child
Child, Preschool
China epidemiology
Environmental Monitoring
Female
Humans
Incidence
Male
Urban Health
Asthma epidemiology
Environmental Exposure
Environmental Pollutants blood
Halogenated Diphenyl Ethers blood
Hydrocarbons, Chlorinated blood
Polychlorinated Biphenyls blood
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0953
- Volume :
- 146
- Database :
- MEDLINE
- Journal :
- Environmental research
- Publication Type :
- Academic Journal
- Accession number :
- 26748225
- Full Text :
- https://doi.org/10.1016/j.envres.2015.12.026