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Improved monitoring of clinical response in Systemic Lupus Erythematosus by longitudinal trend in soluble vascular cell adhesion molecule-1.
- Source :
-
Arthritis research & therapy [Arthritis Res Ther] 2016 Jan 08; Vol. 18, pp. 5. Date of Electronic Publication: 2016 Jan 08. - Publication Year :
- 2016
-
Abstract
- Background: To determine whether optimal use of serial measurements of serum levels of soluble cell adhesion molecules (CAM) can improve monitoring of disease activity in SLE.<br />Methods: Serum levels of soluble CAM and conventional SLE biomarkers were measured in serial samples (nā=ā80) from 21 SLE patients during and after flare and correlated in longitudinal analysis with disease activity determined by ECLAM score. Blood samples from a second cohort of 34 SLE patients were subject to flow cytometry to correlate serum biomarkers with B cell subsets.<br />Results: By adjusting for the baseline level (at the first visit), delta soluble vascular cell adhesion molecule-1 (sVCAM-1) showed stronger correlation with changes in ECLAM score and improved sensitivity and specificity for identifying SLE responders versus non-responders compared to conventional SLE biomarkers including anti-dsDNA antibody titre and complement C3. Multiple regression analysis identified delta sVCAM-1 as the best marker of SLE clinical response. sVCAM-1 levels were significantly correlated with CD95(+)CD27(+) activated memory B cells, CD95(+) plasmablasts and circulating plasma cell numbers in SLE patients.<br />Conclusion: Subtracting a baseline level of sVCAM-1 for each individual substantially improved its utility as a biomarker. Delta sVCAM-1 was superior to conventional SLE biomarkers for monitoring changes in disease activity. This suggests that serial monitoring of serum sVCAM-1 trends should be considered in SLE patients to document responses to treatment. We hypothesise that the correlation between activated B cell subsets and circulating plasma cell numbers with soluble VCAM-1 serum levels in SLE may relate to the important role of VCAM-1 in B lymphocyte survival and maturation in bone marrow and secondary lymphoid tissues.
- Subjects :
- Adult
Biomarkers blood
Cohort Studies
Female
Humans
Longitudinal Studies
Lupus Erythematosus, Systemic therapy
Male
Middle Aged
Monitoring, Physiologic methods
Monitoring, Physiologic trends
Treatment Outcome
Lupus Erythematosus, Systemic blood
Lupus Erythematosus, Systemic diagnosis
Vascular Cell Adhesion Molecule-1 blood
Subjects
Details
- Language :
- English
- ISSN :
- 1478-6362
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Arthritis research & therapy
- Publication Type :
- Academic Journal
- Accession number :
- 26746423
- Full Text :
- https://doi.org/10.1186/s13075-015-0896-7