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Association between the DOCK7, PCSK9 and GALNT2 Gene Polymorphisms and Serum Lipid levels.
- Source :
-
Scientific reports [Sci Rep] 2016 Jan 08; Vol. 6, pp. 19079. Date of Electronic Publication: 2016 Jan 08. - Publication Year :
- 2016
-
Abstract
- This study was to determine the association between several single nucleotide polymorphisms (SNPs) in the dedicator of cytokinesis 7 (DOCK7), proprotein convertase subtilisin/kexin type 9 (PCSK9) and polypeptide N-acetylgalactosaminyltransferase 2 (GALNT2) and serum lipid levels. Genotyping of 9 SNPs was performed in 881 Jing subjects and 988 Han participants. Allele and genotype frequencies of the detected SNPs were different between the two populations. Several SNPs were associated with triglyceride (TG, rs10889332, rs615563, rs7552841, rs1997947, rs2760537, rs4846913 and rs11122316), high-density lipoprotein (HDL) cholesterol (rs1997947), low-density lipoprotein (LDL) cholesterol (rs1168013 and rs7552841), apolipoprotein (Apo) A1 (rs1997947), ApoB (rs10889332 and rs7552841), and ApoA1/ApoB ratio (rs7552841) in Jing minority; and with TG (rs10889332, rs615563, rs7552841, rs11206517, rs1997947, rs4846913 and rs11122316), HDL cholesterol (rs11206517 and rs4846913), LDL cholesterol (rs1168013), ApoA1 (rs11206517 and rs4846913), ApoB (rs7552841), and ApoA1/ApoB ratio (rs4846913) in Han nationality. Strong linkage disequilibria were noted among the SNPs. The commonest haplotype was G-C-G-C-T-G-C-C-G (>10%). The frequencies of C-C-G-C-T-G-T-C-G, G-C-A-C-T-G-C-C-G, G-C-G-C-T-A-C-C-A, G-C-G-C-T-G-C-C-A, G-C-G-C-T-G-T-C-A haplotypes were different between the two populations. Haplotypes could explain much more serum lipid variation than any single SNP alone especially for TG. Differences in lipid profiles between the two populations might partially attribute to these SNPs and their haplotypes.
- Subjects :
- Adult
Aged
Alleles
Cardiovascular Diseases blood
Cardiovascular Diseases ethnology
Cardiovascular Diseases etiology
China
Cholesterol, HDL blood
Cholesterol, LDL blood
Dyslipidemias blood
Dyslipidemias complications
Dyslipidemias ethnology
Ethnicity
Female
GTPase-Activating Proteins blood
Gene Expression Regulation
Gene Frequency
Genome-Wide Association Study
Guanine Nucleotide Exchange Factors
Haplotypes
Humans
Linkage Disequilibrium
Lipid Metabolism genetics
Male
Middle Aged
N-Acetylgalactosaminyltransferases blood
Proprotein Convertase 9 blood
Risk Factors
Triglycerides blood
Polypeptide N-acetylgalactosaminyltransferase
Cardiovascular Diseases genetics
Dyslipidemias genetics
GTPase-Activating Proteins genetics
N-Acetylgalactosaminyltransferases genetics
Polymorphism, Single Nucleotide
Proprotein Convertase 9 genetics
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 6
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 26744084
- Full Text :
- https://doi.org/10.1038/srep19079