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Infectious Spondylitis in a Patient with Chronic Kidney Disease: Identification of Campylobacter fetus Subsp. testudinum by 16S Ribosomal RNA Sequencing.
- Source :
-
Japanese journal of infectious diseases [Jpn J Infect Dis] 2016 Nov 22; Vol. 69 (6), pp. 517-519. Date of Electronic Publication: 2016 Jan 08. - Publication Year :
- 2016
-
Abstract
- We report the first case of spondylitis with bacteremia caused by Campylobacter fetus subsp. testudinum identified by 16S ribosomal ribonucleic acid (rRNA) gene sequencing. An 81-year-old man presented with fever and general weakness. His medical history included end-stage renal disease, hypertension, and type 2 diabetes. Despite empirical antibiotic treatment, his fever and back pain persisted. Magnetic resonance imaging with gadolinium enhancement showed a low-signal-intensity lesion in T1-weighted imaging and a high-signal-intensity lesion in T2-weighted imaging at the L3 vertebral body. C. fetus grew on 1 pair of blood cultures. C. fetus subsp. testudinum was identified via 16S rRNA sequencing of the cultivated organisms. The patient recovered uneventfully after 6 weeks of optimal antibiotic treatment, selected using susceptibility tests. C. fetus spondylitis is a very rare disease. In this unique case involving end-stage renal disease, the underlying pathogen was identified by 16S rRNA sequencing.
- Subjects :
- Aged, 80 and over
Anti-Bacterial Agents therapeutic use
Bacteremia diagnosis
Bacteremia drug therapy
Bacteremia etiology
Bacteremia pathology
Bacteriological Techniques
Campylobacter Infections drug therapy
Campylobacter Infections pathology
Campylobacter fetus classification
Campylobacter fetus genetics
DNA, Ribosomal chemistry
DNA, Ribosomal genetics
Humans
Lumbar Vertebrae diagnostic imaging
Magnetic Resonance Imaging
Male
Sequence Analysis, DNA
Spondylitis drug therapy
Spondylitis pathology
Treatment Outcome
Campylobacter Infections diagnosis
Campylobacter Infections microbiology
Campylobacter fetus isolation & purification
RNA, Ribosomal, 16S genetics
Renal Insufficiency, Chronic complications
Spondylitis diagnosis
Spondylitis etiology
Subjects
Details
- Language :
- English
- ISSN :
- 1884-2836
- Volume :
- 69
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Japanese journal of infectious diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26743148
- Full Text :
- https://doi.org/10.7883/yoken.JJID.2015.461