Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma.

Authors :: Nakashima K
Kodama Y
Nishikawa T
Nishimura M
Ito N
Fukano R
Nomura Y
Ueba T
Inoue T
Oshima K
Okamura J
Inagaki J
Source :: Pediatrics international : official journal of the Japan Pediatric Society [Pediatr Int] 2016 May; Vol. 58 (5), pp. 388-390. Date of Electronic Publication: 2016 Jan 06.
Publication Year :: 2016
Abstract: Epstein-Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.<br /> (© 2016 Japan Pediatric Society.)

Language :: English
ISSN :: 1442-200X
Volume :: 58
Issue :: 5
Database :: MEDLINE
Journal :: Pediatrics international : official journal of the Japan Pediatric Society
Publication Type :: Report
Accession number :: 26738608
Full Text :: https://doi.org/10.1111/ped.12812

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