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Central nervous system EBV lymphoproliferative disorder in a patient with rhabdomyosarcoma.
- Source :
-
Pediatrics international : official journal of the Japan Pediatric Society [Pediatr Int] 2016 May; Vol. 58 (5), pp. 388-390. Date of Electronic Publication: 2016 Jan 06. - Publication Year :
- 2016
-
Abstract
- Epstein-Barr virus associated lymphoproliferative disorder (EBV-LPD) occurs in patients with immunodeficiency, but it has not been well described in patients who have received chemotherapy for solid tumors. We describe a child with rhabdomyosarcoma who developed isolated central nervous system (CNS) EBV-LPD during combination chemotherapy with vincristine, actinomycin D and cyclophosphamide. The patient was treated with high-dose methotrexate (HD-MTX) for CNS EBV-LPD and then treated with rituximab in addition to HD-MTX because of the emergence of LPD in the liver. I.v. rituximab combined with HD-MTX might be effective therapy for CNS EBV-LPD.<br /> (© 2016 Japan Pediatric Society.)
Details
- Language :
- English
- ISSN :
- 1442-200X
- Volume :
- 58
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Pediatrics international : official journal of the Japan Pediatric Society
- Publication Type :
- Report
- Accession number :
- 26738608
- Full Text :
- https://doi.org/10.1111/ped.12812