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Biomimetic hybrid scaffolds for osteo-chondral tissue repair: Design and osteogenic differentiation of human placenta-derived cells (hPDC).

Authors :
Farè S
Bertoldi S
Meskinfam M
Spoldi V
Tanzi MC
Parolini O
Source :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference [Annu Int Conf IEEE Eng Med Biol Soc] 2015 Aug; Vol. 2015, pp. 1753-6.
Publication Year :
2015

Abstract

A novel functionally-graded hybrid (FGHY) scaffold was designed and developed with a load-bearing structure represented by a PU foam loaded with a graded composition of CaPs (biomimetic component) and pectin gel as cell carrier. hPDC populations encapsulated in pectin gels and injected into the FGHY scaffolds demonstrated the ability to differentiate toward the osteogenic lineage. The ability of these biomimetic hybrid scaffolds to stimulate cell adhesion and proliferation and to support differentiation of hPDCs make these scaffolds excellent candidates for an use in bone regeneration.

Details

Language :
English
ISSN :
2694-0604
Volume :
2015
Database :
MEDLINE
Journal :
Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference
Publication Type :
Academic Journal
Accession number :
26736617
Full Text :
https://doi.org/10.1109/EMBC.2015.7318717