Back to Search
Start Over
Mechanical effects of left ventricular midwall fibrosis in non-ischemic cardiomyopathy.
- Source :
-
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance [J Cardiovasc Magn Reson] 2016 Jan 05; Vol. 18, pp. 1. Date of Electronic Publication: 2016 Jan 05. - Publication Year :
- 2016
-
Abstract
- Background: Left ventricular (LV) mid-wall fibrosis (MWF), which occurs in about a quarter of patients with non-ischemic cardiomyopathy (NICM), is associated with high risk of pump failure. The mid LV wall is the site of circumferential myocardial fibers. We sought to determine the effect of MWF on LV myocardial mechanics.<br />Methods: Patients with NICM (n = 116; age: 62.8 ± 13.2 years; 67% male) underwent late gadolinium enhancement cardiovascular magnetic resonance (CMR) and were categorized according to the presence (+) or absence (-) of MWF. Feature tracking (FT) CMR was used to assess myocardial deformation.<br />Results: Despite a similar LVEF (24.3 vs. 27.5%, p = 0.20), patients with MWF (32 [24%]) had lower global circumferential strain (Ɛcc: -6.6% vs. -9.4 %, P = 0.004), but similar longitudinal (Ɛll: -7.6 % vs. -9.4 %, p = 0.053) and radial (Ɛrr: 14.6% vs. 17.8% p = 0.18) strain. Compared with - MWF, + MWF was associated with reduced LV systolic, circumferential strain rate (-0.38 ± 0.1 vs. -0.56 ± 0.3 s(-1), p = 0.005) and peak LV twist (4.65 vs. 6.31°, p = 0.004), as well as rigid LV body rotation (64 % vs. 28 %, P <0.001). In addition, +MWF was associated with reduced LV diastolic strain rates (DSRcc: 0.34 vs. 0.46 s(-1); DSRll: 0.38 vs. 0.50s(-1); DSRrr: -0.55 vs. -0.75 s(-1); all p <0.05).<br />Conclusions: MWF is associated with reduced LV global circumferential strain, strain rate and torsion. In addition, MWF is associated with rigid LV body rotation and reduced diastolic strain rates. These systolic and diastolic disturbances may be related to the increased risk of pump failure observed in patients with NICM and MWF.
- Subjects :
- Aged
Biomechanical Phenomena
Cardiomyopathies complications
Cardiomyopathies pathology
Cardiomyopathies physiopathology
Contrast Media
Diastole
England
Female
Fibrosis
Gadolinium DTPA
Heart Failure etiology
Heart Failure pathology
Heart Failure physiopathology
Heart Ventricles pathology
Humans
Magnetic Resonance Imaging, Cine
Male
Middle Aged
Predictive Value of Tests
Stress, Mechanical
Systole
Torsion, Mechanical
Cardiomyopathies diagnosis
Heart Ventricles physiopathology
Myocardium pathology
Ventricular Function, Left
Subjects
Details
- Language :
- English
- ISSN :
- 1532-429X
- Volume :
- 18
- Database :
- MEDLINE
- Journal :
- Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
- Publication Type :
- Academic Journal
- Accession number :
- 26732096
- Full Text :
- https://doi.org/10.1186/s12968-015-0221-2