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Genetic Structure of a Local Population of the Anopheles gambiae Complex in Burkina Faso.
- Source :
-
PloS one [PLoS One] 2016 Jan 05; Vol. 11 (1), pp. e0145308. Date of Electronic Publication: 2016 Jan 05 (Print Publication: 2016). - Publication Year :
- 2016
-
Abstract
- Members of the Anopheles gambiae species complex are primary vectors of human malaria in Africa. Population heterogeneities for ecological and behavioral attributes expand and stabilize malaria transmission over space and time, and populations may change in response to vector control, urbanization and other factors. There is a need for approaches to comprehensively describe the structure and characteristics of a sympatric local mosquito population, because incomplete knowledge of vector population composition may hinder control efforts. To this end, we used a genome-wide custom SNP typing array to analyze a population collection from a single geographic region in West Africa. The combination of sample depth (n = 456) and marker density (n = 1536) unambiguously resolved population subgroups, which were also compared for their relative susceptibility to natural genotypes of Plasmodium falciparum malaria. The population subgroups display fluctuating patterns of differentiation or sharing across the genome. Analysis of linkage disequilibrium identified 19 new candidate genes for association with underlying population divergence between sister taxa, A. coluzzii (M-form) and A. gambiae (S-form).
- Subjects :
- Animals
Anopheles classification
Burkina Faso epidemiology
Genetics, Population methods
Genotype
Geography
Humans
Insect Vectors classification
Linkage Disequilibrium
Malaria, Falciparum epidemiology
Malaria, Falciparum parasitology
Phylogeny
Population Dynamics
Species Specificity
Anopheles genetics
Genetic Structures
Genome, Insect genetics
Insect Vectors genetics
Polymorphism, Single Nucleotide
Subjects
Details
- Language :
- English
- ISSN :
- 1932-6203
- Volume :
- 11
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- PloS one
- Publication Type :
- Academic Journal
- Accession number :
- 26731649
- Full Text :
- https://doi.org/10.1371/journal.pone.0145308