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Plasmodium falciparum associated placental pathology: a light and electron microscopic and immunohistologic study.
- Source :
-
The American journal of tropical medicine and hygiene [Am J Trop Med Hyg] 1989 Aug; Vol. 41 (2), pp. 161-8. - Publication Year :
- 1989
-
Abstract
- Pathological changes were studied by light and electron microscopy on term placentas collected in Malawi from 20 P. falciparum infected women (11 primiparas and 9 multiparas). One placenta from an uninfected term primipara and 4 from multiparas were studied as controls. Changes included the presence of parasitized erythrocytes and malarial pigment particles in the intervillous space, excessive syncytial knotting, chronic basal villitis, malarial pigment deposits in the trophoblasts, trophoblastic damage with focal necrosis, partial loss of microvilli, and thickening of the trophoblastic basement membrane. Infected erythrocytes were not seen in the fetal circulation. Severity appeared to correlate with the level of maternal and placental parasitemias, regardless of infant birth weight or placental weight. Differences in the severity of pathological changes between primiparas and multiparas could not be demonstrated. Immunohistochemistry revealed that 45% of the placentas stained strongly for IgG and 15% stained for C3 and for P. falciparum antigens in the trophoblastic cytoplasm and basement membrane.
- Subjects :
- Animals
Birth Weight
Erythrocytes parasitology
Female
Humans
Immunoenzyme Techniques
Immunohistochemistry
Infant, Newborn
Malaria metabolism
Malaria parasitology
Microscopy, Electron
Organ Size
Placenta metabolism
Placenta parasitology
Placenta pathology
Placenta Diseases metabolism
Placenta Diseases parasitology
Plasmodium falciparum
Pregnancy
Malaria pathology
Placenta Diseases pathology
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9637
- Volume :
- 41
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- The American journal of tropical medicine and hygiene
- Publication Type :
- Academic Journal
- Accession number :
- 2672835
- Full Text :
- https://doi.org/10.4269/ajtmh.1989.41.161