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Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.
- Source :
-
FASEB journal : official publication of the Federation of American Societies for Experimental Biology [FASEB J] 2016 Apr; Vol. 30 (4), pp. 1683-8. Date of Electronic Publication: 2016 Jan 04. - Publication Year :
- 2016
-
Abstract
- Academic achievement in adolescents is correlated with 1-carbon metabolism (1-CM), as folate intake is positively related and total plasma homocysteine (tHcy) negatively related to academic success. Because another 1-CM nutrient, choline is essential for fetal neurocognitive development, we hypothesized that choline and betaine could also be positively related to academic achievement in adolescents. In a sample of 15-yr-old children (n= 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamineN-methyltransferase (PEMT), rs12325817 (G>C). The sum of school grades in 17 major subjects was used as an outcome measure for academic achievement. Lifestyle and family socioeconomic status (SES) data were obtained from questionnaires. Plasma choline was significantly and positively associated with academic achievement independent of SES factors (paternal education and income, maternal education and income, smoking, school) and of folate intake (P= 0.009,R(2)= 0.285). With the addition of thePEMTrs12325817 polymorphism, the association value was only marginally changed. Plasma betaine concentration, tHcy, and theMTHFR677C>T polymorphism did not affect academic achievement in any tested model involving choline. Dietary intake of choline is marginal in many adolescents and may be a public health concern.-Nilsson, T. K., Hurtig-Wennlöf, A., Sjöström, M., Herrmann, W., Obeid, R., Owen, J. R., Zeisel, S. Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents.<br /> (© FASEB.)
- Subjects :
- Adolescent
Cross-Sectional Studies
Female
Genotype
Humans
Linear Models
Male
Polymorphism, Single Nucleotide
Social Class
Surveys and Questionnaires
Betaine blood
Choline blood
Educational Status
Homocysteine blood
Methylenetetrahydrofolate Reductase (NADPH2) genetics
Phosphatidylethanolamine N-Methyltransferase genetics
Subjects
Details
- Language :
- English
- ISSN :
- 1530-6860
- Volume :
- 30
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- FASEB journal : official publication of the Federation of American Societies for Experimental Biology
- Publication Type :
- Academic Journal
- Accession number :
- 26728177
- Full Text :
- https://doi.org/10.1096/fj.15-281097