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Evidence of co-infection with Mycobacterium bovis and tick-borne pathogens in a naturally infected sheep flock.
- Source :
-
Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2016 Mar; Vol. 7 (2), pp. 384-9. Date of Electronic Publication: 2015 Dec 17. - Publication Year :
- 2016
-
Abstract
- Ticks are responsible for the transmission of pathogens of veterinary importance, including those affecting sheep. The current study was designed to investigate co-infections with tick-borne and other pathogens in a naturally infected sheep flock with poor health condition using serology and PCR. Infection with Anaplasma ovis was detected by serology and PCR in 56% of the animals. The presence of Rickettsia spp. of the Spotted Fever Group (SFG) was detected by PCR and sequence analysis in 31% of the animals. All the animals were negative for Anaplasma phagocytophilum either by serology or PCR. Twelve sheep were randomly selected for anatomopathological studies. Five of these animals presented lesions consistent with Mycobacterium tuberculosis complex (MTBC) infection and spoligotyping confirmed infection with Mycobacterium bovis spoligotype SB0339. Co-infection with tick-borne pathogens and MTBC could contribute to the poor health condition observed in these animals but other uncontrolled factors may also be responsible. The differential expression of immune response genes supported previous findings in ruminants and suggested that infection with tick-borne pathogens and M. bovis may results in unique gene expression patterns in sheep. The results underline the need for further research into the possible role of sheep in the epidemiology of animal tuberculosis.<br /> (Copyright © 2015 Elsevier GmbH. All rights reserved.)
- Subjects :
- Anaplasma ovis genetics
Anaplasma ovis immunology
Animals
Arachnid Vectors microbiology
Coinfection veterinary
Female
Mycobacterium bovis genetics
Rickettsia genetics
Sequence Analysis, DNA veterinary
Sheep
Sheep Diseases epidemiology
Spain epidemiology
Tick-Borne Diseases epidemiology
Tick-Borne Diseases microbiology
Ticks microbiology
Tuberculosis epidemiology
Tuberculosis microbiology
Anaplasma ovis isolation & purification
Mycobacterium bovis isolation & purification
Rickettsia isolation & purification
Sheep Diseases microbiology
Tick-Borne Diseases veterinary
Tuberculosis veterinary
Subjects
Details
- Language :
- English
- ISSN :
- 1877-9603
- Volume :
- 7
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Ticks and tick-borne diseases
- Publication Type :
- Academic Journal
- Accession number :
- 26726806
- Full Text :
- https://doi.org/10.1016/j.ttbdis.2015.12.013