Back to Search
Start Over
Analysis of Assembly and Budding of Lujo Virus.
- Source :
-
Journal of virology [J Virol] 2015 Dec 30; Vol. 90 (6), pp. 3257-61. Date of Electronic Publication: 2015 Dec 30. - Publication Year :
- 2015
-
Abstract
- The recently identified arenavirus Lujo virus (LUJV) causes fatal hemorrhagic fever in humans. We analyzed its mechanism of viral release driven by matrix protein Z and the cell surface glycoprotein precursor GPC. The L domains in Z are required for efficient virus-like particle release, but Tsg101, ALIX/AIP1, and Vps4A/B are unnecessary for budding. LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
Details
- Language :
- English
- ISSN :
- 1098-5514
- Volume :
- 90
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Journal of virology
- Publication Type :
- Academic Journal
- Accession number :
- 26719243
- Full Text :
- https://doi.org/10.1128/JVI.03198-15