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Epicardium-derived fibroblasts in heart development and disease.
- Source :
-
Journal of molecular and cellular cardiology [J Mol Cell Cardiol] 2016 Feb; Vol. 91, pp. 23-7. Date of Electronic Publication: 2015 Dec 22. - Publication Year :
- 2016
-
Abstract
- The majority of cardiac fibroblasts in a mature mammalian heart are derived from the epicardium during prenatal development and reactivate developmental programs during the progression of fibrotic disease. In addition, epicardial activation, proliferation, and fibrosis occur with ischemic, but not hypertensive injury. Here we review cellular and molecular mechanisms that control epicardium-derived cell lineages during development and disease with a focus on cardiac fibroblasts. This article is part of a special issue entitled "Fibrosis and Myocardial Remodeling".<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Animals
Cell Differentiation
Cell Lineage physiology
Cell Proliferation
Fibroblasts metabolism
Fibrosis
Humans
Myocardial Infarction metabolism
Myocardium metabolism
Myocardium pathology
Myocytes, Cardiac metabolism
Organogenesis physiology
Pericardium metabolism
Fibroblasts pathology
Myocardial Infarction pathology
Myocytes, Cardiac pathology
Pericardium pathology
Subjects
Details
- Language :
- English
- ISSN :
- 1095-8584
- Volume :
- 91
- Database :
- MEDLINE
- Journal :
- Journal of molecular and cellular cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 26718723
- Full Text :
- https://doi.org/10.1016/j.yjmcc.2015.12.019