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Protein-protein interactions among signaling pathways may become new therapeutic targets in liver cancer (Review).
- Source :
-
Oncology reports [Oncol Rep] 2016 Feb; Vol. 35 (2), pp. 625-38. Date of Electronic Publication: 2015 Nov 27. - Publication Year :
- 2016
-
Abstract
- Numerous signaling pathways have been shown to be dysregulated in liver cancer. In addition, some protein-protein interactions are prerequisite for the uncontrolled activation or inhibition of these signaling pathways. For instance, in the PI3K/AKT signaling pathway, protein AKT binds with a number of proteins such as mTOR, FOXO1 and MDM2 to play an oncogenic role in liver cancer. The aim of the present review was to focus on a series of important protein-protein interactions that can serve as potential therapeutic targets in liver cancer among certain important pro-carcinogenic signaling pathways. The strategies of how to investigate and analyze the protein-protein interactions are also included in this review. A survey of these protein interactions may provide alternative therapeutic targets in liver cancer.
Details
- Language :
- English
- ISSN :
- 1791-2431
- Volume :
- 35
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- Oncology reports
- Publication Type :
- Academic Journal
- Accession number :
- 26717966
- Full Text :
- https://doi.org/10.3892/or.2015.4464