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Th17 cells reflect colon submucosal pathologic changes in active eosinophilic granulomatosis with polyangiitis.
- Source :
-
BMC immunology [BMC Immunol] 2015 Dec 29; Vol. 16, pp. 75. Date of Electronic Publication: 2015 Dec 29. - Publication Year :
- 2015
-
Abstract
- Background: Chronic eosinophilic pneumonia (CEP) or eosinophilic gastroenteritis (EG), or both, with asthma precede the onset of eosinophilic granulomatosis with polyangiitis (EGPA) in half of all EGPA patients. It is not known what determines whether patients with CEP or with EG following asthma will develop EGPA.<br />Methods: We studied 17 EGPA patients and 12 patients with CEP but without EGPA. We assayed serum ICAM-1, VCAM-1, and VEGF, and the percentage of peripheral blood CD4(+) T cells producing IL-17 (Th17 cells), at both onset and remission. We also examined the numbers of submucosal eosinophils and the basement membrane-to-crypt and crypt-to-crypt distance to evaluate edema in the colon submucosa at onset and remission in EGPA and at onset in CEP.<br />Results: Nine of 12 (75.0%) CEP patients had symptoms or endoscopic findings. Colonic submucosal eosinophil counts and edema in EGPA at onset were greater than at remission or in CEP at onset. Th17 cells (%) and serum ICAM-1 levels at onset were greater in EGPA than in CEP. In EGPA, peripheral blood Th17 cells (%) were significantly correlated with serum ICAM-1 level, colonic submucosal eosinophil count, and degree of edematous change; inversely correlated with serum VEGF level; but not correlated with VCAM-1 level.<br />Conclusions: Eosinophilia and colonic submucosal edematous change were greater in EGPA than in CEP. The mechanism of vasculitis in EGPA appears related to increases in serum Th17 cell numbers and ICAM-1 levels and decreases in VEGF levels.
- Subjects :
- Adult
Biomarkers
Colon metabolism
Comorbidity
Endoscopy, Gastrointestinal
Enteritis complications
Enteritis diagnosis
Enteritis immunology
Enteritis metabolism
Enteritis pathology
Eosinophilia complications
Eosinophilia diagnosis
Eosinophilia metabolism
Female
Gastritis complications
Gastritis diagnosis
Gastritis immunology
Gastritis metabolism
Gastritis pathology
Granulomatosis with Polyangiitis diagnosis
Humans
Intercellular Adhesion Molecule-1 blood
Intestinal Mucosa immunology
Intestinal Mucosa metabolism
Intestinal Mucosa pathology
Leukocyte Count
Male
Middle Aged
Pulmonary Eosinophilia complications
Pulmonary Eosinophilia diagnosis
Pulmonary Eosinophilia immunology
Pulmonary Eosinophilia metabolism
Pulmonary Eosinophilia pathology
Th17 Cells metabolism
Vascular Cell Adhesion Molecule-1 blood
Vascular Endothelial Growth Factor A blood
Colon immunology
Colon pathology
Eosinophilia immunology
Eosinophilia pathology
Granulomatosis with Polyangiitis etiology
Granulomatosis with Polyangiitis pathology
Th17 Cells immunology
Subjects
Details
- Language :
- English
- ISSN :
- 1471-2172
- Volume :
- 16
- Database :
- MEDLINE
- Journal :
- BMC immunology
- Publication Type :
- Academic Journal
- Accession number :
- 26714881
- Full Text :
- https://doi.org/10.1186/s12865-015-0138-4