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C646, a Novel p300/CREB-Binding Protein-Specific Inhibitor of Histone Acetyltransferase, Attenuates Influenza A Virus Infection.
- Source :
-
Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2015 Dec 28; Vol. 60 (3), pp. 1902-6. Date of Electronic Publication: 2015 Dec 28. - Publication Year :
- 2015
-
Abstract
- New strategies to develop novel broad-spectrum antiviral drugs against influenza virus infections are needed due to the emergence of antigenic variants and drug-resistant viruses. Here, we evaluated C646, a novel p300/CREB-binding protein-specific inhibitor of histone acetyltransferase (HAT), as an anti-influenza virus agent in vitro and in vivo and explored how C646 affects the viral life cycle and host response. Our studies highlight the value of targeting HAT activity for anti-influenza drug development.<br /> (Copyright © 2016, American Society for Microbiology. All Rights Reserved.)
- Subjects :
- Animals
CREB-Binding Protein metabolism
Cell Line
Dogs
E1A-Associated p300 Protein metabolism
HEK293 Cells
Humans
Madin Darby Canine Kidney Cells
Mice
Mice, Inbred BALB C
Nitrobenzenes
Pyrazolones
Antiviral Agents pharmacology
Benzoates pharmacology
CREB-Binding Protein antagonists & inhibitors
E1A-Associated p300 Protein antagonists & inhibitors
Histone Acetyltransferases antagonists & inhibitors
Influenza A virus drug effects
Orthomyxoviridae Infections drug therapy
Pyrazoles pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1098-6596
- Volume :
- 60
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Antimicrobial agents and chemotherapy
- Publication Type :
- Academic Journal
- Accession number :
- 26711748
- Full Text :
- https://doi.org/10.1128/AAC.02055-15