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Short article: Hepatitis B virus status in children born to HIV/HBV coinfected women in a French hospital: a cross-sectional study.
- Source :
-
European journal of gastroenterology & hepatology [Eur J Gastroenterol Hepatol] 2016 Mar; Vol. 28 (3), pp. 328-32. - Publication Year :
- 2016
-
Abstract
- Objectives: We assessed hepatitis B virus (HBV) status in children born to HIV/HBV coinfected women with large access to antiretroviral therapy.<br />Methods: All HIV/HBV coinfected pregnant women from 01 January 2000 to 01 January 2012 were included in the retrospective study (NCT02044068). Antiretroviral therapy during pregnancy and injection of HBV immunoglobulin/vaccine to newborns was recorded. We assessed HBV status of children aged at least 2 years.<br />Results: Twenty-one women (35 children) were studied. Twenty-six children (74%) had HBsAb: 22 had received immunoglobulin and 24 had received a complete vaccine (with immunoglobulin in 21 cases); their mothers had been administered lamivudine or tenofovir/emtricitabine during eight and nine pregnancies, respectively. Eight children (23%) were negative for HBsAg, HBsAb, and HBcAb: four (11.5%) had received immunoglobulin and a complete vaccine; in two children, it was not known whether they had received an immunoglobulin injection; in one child, the vaccine was incomplete; and in the last one, it was not known whether he had received immunoglobulin/vaccine. Their mothers had been administered lamivudine or tenofovir/emtricitabine during five and two pregnancies, respectively. No infant has chronic HBV infection (HBsAg) after prenatal mothers' antiretroviral therapy combined with a complete postnatal HBV protection. One child had HBcAb and HBsAb: it was not known whether she had received an immunoglobulin injection; the vaccine was incomplete. The mother had been administered lamivudine during the last trimester of pregnancy.<br />Conclusion: Antiretroviral therapy in HBV/HIV coinfected women following current national HBV guidelines may prevent mother-to-child-transmission of HBV. Negativity of surrogate markers of vaccine-induced protection is frequent; large studies on long-term protection are needed.
- Subjects :
- Adolescent
Anti-HIV Agents therapeutic use
Anti-Retroviral Agents therapeutic use
Child
Child, Preschool
Cross-Sectional Studies
Female
France
HIV Infections diagnosis
HIV Infections drug therapy
Hepatitis B diagnosis
Hepatitis B drug therapy
Hepatitis B Antibodies blood
Hepatitis B Surface Antigens blood
Hepatitis B Vaccines therapeutic use
Humans
Immunoglobulins therapeutic use
Pregnancy
Pregnancy Complications, Infectious diagnosis
Pregnancy Complications, Infectious drug therapy
Retrospective Studies
Time Factors
Treatment Outcome
Coinfection
HIV Infections virology
Hepatitis B transmission
Hepatitis B virology
Infectious Disease Transmission, Vertical prevention & control
Pregnancy Complications, Infectious virology
Subjects
Details
- Language :
- English
- ISSN :
- 1473-5687
- Volume :
- 28
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- European journal of gastroenterology & hepatology
- Publication Type :
- Academic Journal
- Accession number :
- 26709883
- Full Text :
- https://doi.org/10.1097/MEG.0000000000000559