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Design, synthesis and bioactivity evaluation of Galf mimics as antitubercular agents.
- Source :
-
Carbohydrate research [Carbohydr Res] 2016 Jun 24; Vol. 429, pp. 135-42. Date of Electronic Publication: 2015 Dec 02. - Publication Year :
- 2016
-
Abstract
- A series of novel Galf mimics has been synthesized and characterized by IR, (1)H NMR, (13)C NMR, mass spectral and element analysis. All the newly prepared compounds were screened for their antitubercular activities. Bioactivity assays manifested that most of Galf mimics exhibited good antitubercular activities. Especially compound 4d and 4e displayed remarkable antitubercular efficacies, which were comparable to ethambutol.<br /> (Copyright © 2015 Elsevier Ltd. All rights reserved.)
- Subjects :
- Antitubercular Agents pharmacology
Cell Wall metabolism
Ethambutol pharmacology
Fungal Proteins genetics
Fungal Proteins metabolism
Galactose analogs & derivatives
Galactose chemistry
Galactose genetics
Galactose metabolism
Gene Expression
Glycoconjugates chemistry
Imino Furanoses chemistry
Intramolecular Transferases genetics
Intramolecular Transferases metabolism
Microbial Sensitivity Tests
Molecular Mimicry
Mycobacterium tuberculosis genetics
Mycobacterium tuberculosis metabolism
Transferases genetics
Transferases metabolism
Uridine Diphosphate analogs & derivatives
Uridine Diphosphate chemistry
Uridine Diphosphate genetics
Uridine Diphosphate metabolism
Antitubercular Agents chemical synthesis
Cell Wall drug effects
Drug Design
Glycoconjugates antagonists & inhibitors
Mycobacterium tuberculosis drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1873-426X
- Volume :
- 429
- Database :
- MEDLINE
- Journal :
- Carbohydrate research
- Publication Type :
- Academic Journal
- Accession number :
- 26706033
- Full Text :
- https://doi.org/10.1016/j.carres.2015.11.002