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Quinic acid derivatives inhibit dengue virus replication in vitro.
- Source :
-
Virology journal [Virol J] 2015 Dec 22; Vol. 12, pp. 223. Date of Electronic Publication: 2015 Dec 22. - Publication Year :
- 2015
-
Abstract
- Background: Dengue is the most prevalent arboviral disease in tropical and sub-tropical areas of the world. The incidence of infection is estimated to be 390 million cases and 25,000 deaths per year. Despite these numbers, neither a specific treatment nor a preventive vaccine is available to protect people living in areas of high risk.<br />Results: With the aim of seeking a treatment that can mitigate dengue infection, we demonstrated that the quinic acid derivatives known as compound 2 and compound 10 were effective against all four dengue virus serotypes and safe for use in a human hepatoma cell line (Huh7.5). Both compounds were non-virucidal to dengue virus particles and did not interfere with early steps of the dengue virus life cycle, including binding and internalization. Experiments using a replicon system demonstrated that compounds 2 and 10 impaired dengue virus replication in Huh7.5 cells. Additionally, the anti-dengue virus effects of the quinic acid derivatives were preserved in human peripheral blood mononuclear cells.<br />Conclusions: Taken together, these data suggest that quinic acid derivatives represent a novel chemical class of active compounds that could be used to combat dengue virus infection.
- Subjects :
- Animals
Antiviral Agents chemistry
Antiviral Agents toxicity
Cell Line
Cell Survival drug effects
Culicidae
Hepatocytes drug effects
Humans
Microbial Sensitivity Tests
Microbial Viability drug effects
Models, Molecular
Molecular Structure
Quinic Acid chemistry
Quinic Acid toxicity
Antiviral Agents pharmacology
Dengue Virus drug effects
Dengue Virus physiology
Quinic Acid analogs & derivatives
Quinic Acid pharmacology
Virus Replication drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1743-422X
- Volume :
- 12
- Database :
- MEDLINE
- Journal :
- Virology journal
- Publication Type :
- Academic Journal
- Accession number :
- 26695767
- Full Text :
- https://doi.org/10.1186/s12985-015-0443-9